A heat-sensitive TRP channel expressed in keratinocytes
| Autor: | Andrea M. Peier, Alison J. Reeve, John B. Hogenesch, David Andersson, Peter McIntyre, Gina M. Story, Sian Colley, Ardem Patapoutian, Stuart Bevan, Taryn J. Earley, Anne C. Hergarden, Aziz Moqrich |
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| Rok vydání: | 2002 |
| Předmět: |
Keratinocytes
TRPV3 Hot Temperature Patch-Clamp Techniques Molecular Sequence Data TRPV Cation Channels Sensory system CHO Cells TRPP TRPV Ion Channels Cell Line Membrane Potentials Heat sensitive Transient receptor potential channel Mice Cricetinae Ganglia Spinal medicine Animals Humans Amino Acid Sequence RNA Messenger Cloning Molecular Cation Transport Proteins Cells Cultured In Situ Hybridization Cloning Nerve Endings Neurons Multidisciplinary Chemistry Temperature Anatomy Blotting Northern Ruthenium Red Cell biology medicine.anatomical_structure Animals Newborn Epidermal Cells Spinal Cord Capsaicin Epidermis Keratinocyte Signal Transduction |
| Zdroj: | Science (New York, N.Y.). 296(5575) |
| ISSN: | 1095-9203 |
| Popis: | Mechanical and thermal cues stimulate a specialized group of sensory neurons that terminate in the skin. Three members of the transient receptor potential (TRP) family of channels are expressed in subsets of these neurons and are activated at distinct physiological temperatures. Here, we describe the cloning and characterization of a novel thermosensitive TRP channel. TRPV3 has a unique threshold: It is activated at innocuous (warm) temperatures and shows an increased response at noxious temperatures. TRPV3 is specifically expressed in keratinocytes; hence, skin cells are capable of detecting heat via molecules similar to those in heat-sensing neurons. |
| Databáze: | OpenAIRE |
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