Differential ultrastructural distribution of synapsin and synaptophysin proximal to a ligation in bovine splenic nerve
| Autor: | W.P. De Potter, P. Partoens, J. Quatacker |
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| Rok vydání: | 1998 |
| Předmět: |
Male
medicine.medical_specialty Immunocytochemistry Synaptophysin Synaptic vesicle Nervous System Vas Deferens Internal medicine medicine Animals Tissue Distribution Molecular Biology Ligation biology General Neuroscience Vesicle Vas deferens Synapsin Synapsins Cell biology Endocrinology medicine.anatomical_structure nervous system Axoplasmic transport biology.protein Ultrastructure Cattle Neurology (clinical) Spleen Developmental Biology |
| Zdroj: | Brain research |
| ISSN: | 0006-8993 |
| Popis: | Synaptophysin and synapsin, closely correlated on synaptic vesicles in terminals, may show a differential distribution at synapse formation and maturation. In order to disclose the fine structural details of these differences, synapsin and synaptophysin distribution was studied by immunocytochemistry on ligated bovine splenic axons in vitro and compared with terminals in the vas deferens. In the synaptic differentiations taking place proximally synapsin could only be detected on the accumulating elements of the axonal reticulum. Large dense granules and clusters of small synaptic vesicles were negative. Synaptophysin was restricted to these clusters. In the vas deferens, co-localization of synapsin and synaptophysin could be seen on small vesicles. From their formation small synaptic vesicles carry synaptophysin. Synapsin may be involved in the dynamic membrane changes taking place at the ligation. At a functional terminal, synapsin shifts to small synaptic vesicles. |
| Databáze: | OpenAIRE |
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