Effect of N-acetylcysteine(NAC) treatment on HIV-1 infection: a double-blind placebo-controlled trial
| Autor: | B. Lindeke, A.-C. Åkerblad, Anders Sönnerborg, Connie Jarstrand, B. Åkerlund, O. Rasool |
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| Rok vydání: | 1996 |
| Předmět: |
Adult
Male medicine.medical_specialty Neutrophils medicine.medical_treatment Placebo-controlled study HIV Infections Placebo Gastroenterology Asymptomatic Antiviral Agents law.invention Acetylcysteine Randomized controlled trial Double-Blind Method law Superoxides Internal medicine medicine Humans Pharmacology (medical) Cysteine Aged Pharmacology Chemotherapy business.industry Tumor Necrosis Factor-alpha Nitroblue Tetrazolium General Medicine Free Radical Scavengers Middle Aged CD4 Lymphocyte Count Clinical trial Immunology HIV-1 Tumor necrosis factor alpha Female medicine.symptom business medicine.drug |
| Zdroj: | European journal of clinical pharmacology. 50(6) |
| ISSN: | 0031-6970 |
| Popis: | In a double-blind placebo-controlled trial, human immunodeficiency virus (HIV)-seropositive patients with a CD4 lymphocyte cell count of more than 200 x 10(6) . l-1 were randomised to receive either 800 mg N-acetylcysteine (NAC) or placebo for 4 months. Before treatment low plasma cysteine levels, high free radical activity in neutrophils in the presence of autologous plasma-measured by the nitroblue tetrazolium (NBT) test- and increased tumor necrosis factor (TNF)-alpha levels were found in the HIV positive patients.After treatment the low plasma cysteine level in the NAC group increased to normal, and the decline of the CD4+ lymphocyte count before the study start, was less steep in the NAC group than in the placebo group after treatment. There was also a reduction in TNF-alpha level. However, NAC had no effect on the radical production by neutrophils, and although it did not increase the CD4+ cell count, it may have decreased the decline in CD4+ cells.Further controlled trials with NAC are needed to determine whether it has a beneficial effect in the treatment of asymptomatic HIV-infected individuals. |
| Databáze: | OpenAIRE |
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