Current epidemiology and antimicrobial resistance data for bacterial bloodstream infections in patients with hematologic malignancies: an Italian multicentre prospective survey
| Autor: | Nicola Vianelli, Anna Candoni, Morena Caira, Livio Pagano, Antonio Spadea, Domenico Pastore, Alessandro Busca, Annamaria Nosari, R Fanci, Enrico Maria Trecarichi, Mario Tumbarello, Cristina Cattaneo |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Microbiology (medical) Epidemiology Antimicrobial resistance Bacterial bloodstream infections Hematologic cancer Mortality Multidrug resistance Bacteremia Biology Gram-Positive Bacteria bacterial bloodstream infections Settore MED/17 - MALATTIE INFETTIVE Tazobactam Meropenem Microbiology Tertiary Care Centers Antibiotic resistance multidrug resistance Drug Resistance Bacterial Gram-Negative Bacteria medicine Humans Prospective Studies Aged Teicoplanin General Medicine Middle Aged biology.organism_classification mortality Acinetobacter baumannii Settore MED/15 - MALATTIE DEL SANGUE Infectious Diseases Italy Amikacin Hematologic Neoplasms hematologic cancer Female epidemiology Gentamicin medicine.drug Piperacillin |
| Zdroj: | Clinical Microbiology and Infection. 21:337-343 |
| ISSN: | 1198-743X |
| DOI: | 10.1016/j.cmi.2014.11.022 |
| Popis: | A prospective cohort study was conducted in nine hematology wards at tertiary care centres or at university hospitals located throughout Italy from January 2009 to December 2012. All of the cases of bacterial bloodstream infection (BBSI) occurring in adult patients with hematologic malignancies were included. A total of 668 bacterial isolates were recovered in 575 BBSI episodes. Overall, the susceptibility rates of Gram-negative bacteria were 59.1% to ceftazidime, 20.1% to ciprofloxacin, 79.1% to meropenem, 85.2% to amikacin, 69.2% to gentamicin and 69.8% to piperacillin/tazobactam. Resistance to third-generation cephalosporins was found in 98/265 (36.9%) of Enterobacteriaceae isolates. Among Klebsiella pneumoniae strains, 15/43 (34.9%) were resistant to carbapenems. Of 66 Pseudomonas aeruginosa isolates, 46 (69.7%) were multidrug resistant. Overall, the susceptibility rates of Gram-positive bacteria were 97.4% to vancomycin and 94.2% to teicoplanin. Among the monomicrobial cases of BBSI, the 21-day mortality rate was significantly higher for those caused by Gram-negative bacteria compared to those caused by Gram-positive bacteria (47/278, 16.9% vs. 12/212, 5.6%; p |
| Databáze: | OpenAIRE |
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