Heart beat but not respiration is the main driving force of the systemic venous return in the Fontan circulation
| Autor: | Abdullah A. L. Bulushi, Hans-Heiner Kramer, Jens Scheewe, Dominik Daniel Gabbert, Philip Wegner, Inga Voges, Arash Kheradvar, Michael Jerosch-Herold, Mona Salehi Ravesh, Ines Kristo, Christopher Hart, Carsten Rickers |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Vena Cava medicine.medical_treatment lcsh:Medicine Fontan Procedure Cardiovascular Congenital 0302 clinical medicine Heart Rate Respiratory system Child lcsh:Science Heart Defects Pediatric Multidisciplinary Respiration Other Physical Sciences Heart Disease Liver Congestive hepatopathy medicine.vein Cardiology Heart beat cardiovascular system Female Blood Flow Velocity Inferior medicine.medical_specialty Adolescent Hepatic Veins Inferior vena cava Article Fontan circulation Fontan procedure 03 medical and health sciences Internal medicine medicine Humans Preschool business.industry lcsh:R Perinatal Period - Conditions Originating in Perinatal Period medicine.disease 030104 developmental biology Regional Blood Flow lcsh:Q Biochemistry and Cell Biology Digestive Diseases business Venous Pressure 030217 neurology & neurosurgery Venous return curve |
| Zdroj: | Scientific Reports Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019) Gabbert, Dominik Daniel; Hart, Christopher; Jerosch-Herold, Michael; Wegner, Philip; Ravesh, Mona Salehi; Voges, Inga; et al.(2019). Heart beat but not respiration is the main driving force of the systemic venous return in the Fontan circulation.. Scientific reports, 9(1), 2034. doi: 10.1038/s41598-019-38848-5. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/3pp4v80z Scientific reports, vol 9, iss 1 |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-019-38848-5. |
| Popis: | The Fontan procedure provides relief from cyanosis in patients with univentricular hearts. A major clinical unmet need is to understand whether the venous flow patterns of the Fontan circulation lead to the development of congestive hepatopathy and other life-threatening complications. Currently, there is no consensus on whether heart beat or respiration is the main driving force of venous return and which one affects the periodic flow changes for the most (i. e., pulsatility). The present study, for the first time, quantified respiratory and cardiac components of the venous flow in the inferior vena cava (IVC) of 14 Fontan patients and 11 normal controls using a novel approach (“physio-matrix”). We found that in contrast to the normal controls, respiration in Fontan patients had a significant effect on venous flow pulsatility, and the ratio of respiration-dependent to the cardiac-dependent pulsatility was positively associated with the retrograde flow. Nevertheless, the main driving force of net IVC flow was the heart beat and not respiration. The separate analysis of the effects of respiration and heart beat provides new insights into the abnormal venous return patterns that may be responsible for adverse effects on liver and bowel of the patients with Fontan circulation. |
| Databáze: | OpenAIRE |
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