Role of agmatine in the application of neural progenitor cell in central nervous system diseases: therapeutic potentials and effects
| Autor: | Jong Youl Kim, Jong Eun Lee, Sumit Barua, Renée Kosonen |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Histology
Agmatine Arginine Central nervous system Hippocampus Review Article Biology Neuroprotection 03 medical and health sciences Cellular and Molecular Neuroscience chemistry.chemical_compound 0302 clinical medicine medicine Progenitor cell 0303 health sciences Cellular and Molecular Researches Therapeutic uses Cell Biology Neural stem cell medicine.anatomical_structure 030301 anatomy & morphology chemistry Neural progenitor stem cells Anatomy Arginine decarboxylase Neuroscience 030217 neurology & neurosurgery Developmental Biology |
| Zdroj: | Anatomy & Cell Biology |
| ISSN: | 2093-3673 2093-3665 |
| DOI: | 10.5115/acb.21.089 |
| Popis: | Agmatine, the primary decarboxylation product of L-arginine, generated from arginine decarboxylase. Since the discovery of agmatine in the mammalian brain in the 1990s, an increasing number of agmatine-mediated effects have been discovered, demonstrating the benefits of agmatine on ischemic strokes, traumatic brain injury and numerous psychological disorders such as depression, anxiety, and stress. Agmatine also has cellular protective effects and contributes to cell proliferation and differentiation in the central nervous system (CNS). Neural progenitor cells are an important component in the recovery and repair of many neurological disorders due to their ability to differentiate into functional adult neurons. Recent data has revealed that agmatine can regulate and increase proliferation and the fate of progenitor cells in the adult hippocampus. This review aims to summarise and discuss the role of agmatine in the CNS; specifically, the effects and relationship between agmatine and neural progenitor cells and how these ideas can be applied to potential therapeutic application. |
| Databáze: | OpenAIRE |
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