En Face Optical Coherence Tomography Analysis to Assess the Spectrum of Perivenular Ischemia and Paracentral Acute Middle Maculopathy in Retinal Vein Occlusion

Autor: K. Bailey Freund, Nopasak Phasukkijwatana, Srinivas R. Sadda, Emmett T. Cunningham, Rosa Dolz-Marco, Lee M. Jampol, Richard B Rosen, Khalil Ghasemi Falavarjani, H. Richard McDonald, Philipp Roberts, David Sarraf, Ananda Kalevar, Irena Tsui
Rok vydání: 2016
Předmět:
0301 basic medicine
Male
Fovea Centralis
Visual acuity
genetic structures
Visual Acuity
chemistry.chemical_compound
0302 clinical medicine
Ischemia
Occlusion
Macula Lutea
Fluorescein Angiography
Aged
80 and over
medicine.diagnostic_test
Anatomy
Middle Aged
Fluorescein angiography
medicine.anatomical_structure
Acute Disease
Female
medicine.symptom
Tomography
Optical Coherence
Adult
medicine.medical_specialty
Central retinal vein
Retinal Vein
Fundus Oculi
03 medical and health sciences
Young Adult
Retinal Diseases
Ophthalmology
Retinal Vein Occlusion
medicine
Humans
Aged
Retrospective Studies
Retinal Vascular Occlusion
business.industry
Retinal
medicine.disease
eye diseases
030104 developmental biology
chemistry
030221 ophthalmology & optometry
Maculopathy
sense organs
business
Follow-Up Studies
Zdroj: American journal of ophthalmology. 177
ISSN: 1879-1891
Popis: Purpose To assess the spectrum of perivenular ischemia in eyes with retinal vascular obstruction (typically central or hemicentral retinal vein obstruction) using en face optical coherence tomography (OCT). Design Retrospective observational case series. Methods Eyes with recent retinal vascular occlusion illustrating paracentral acute middle maculopathy (PAMM) in a perivenular fern-like pattern with en face OCT were evaluated in this study. Multimodal retinal imaging including en face OCT segmentation of the inner nuclear layer was performed in all patients. Color fundus photography and fluorescein angiography (FA) images were used to create a vascular overlay of the retinal veins vs the retinal arteries to map the distribution of PAMM with en face OCT analysis. Results Multimodal retinal imaging was performed in 11 eyes with acute retinal vascular obstruction. While 7 eyes demonstrated obvious findings of retinal vein obstruction (5 with central and 2 with hemicentral retinal vein occlusion), 4 eyes were unremarkable at presentation. En face OCT analysis demonstrated a spectrum of perivenular PAMM illustrating a fern-like pattern with sparing of the periarteriolar area in all cases. Conclusion En face OCT may illustrate a remarkable perivenular pattern of PAMM in eyes with retinal vascular obstruction even in the absence of significant funduscopic findings. Perivenular PAMM with en face OCT demonstrates a wide spectrum of variation with narrow fern-like perivenular lesions at the mildest end and more diffuse lesions with only periarterial sparing at the most severe end of the spectrum. Arterial hypoperfusion secondary to outflow obstruction from a central retinal vein obstruction appears to be the most common cause of this presentation, although primary arterial hypoperfusion may also be an etiology.
Databáze: OpenAIRE
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