Programmed Cell Death and Inflammation: Winter Is Coming
| Autor: | Andrew Oberst, Thomas H. Oguin, Jennifer Martinez, Joseph P. Kolb |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Programmed cell death Phagocyte Phagocytosis Immunology Apoptosis Inflammation Biology Article 03 medical and health sciences Immune system medicine Animals Homeostasis Humans Immunology and Allergy Efferocytosis Mononuclear Phagocyte System Phagocytes Innate immune system Immunity Innate 030104 developmental biology medicine.anatomical_structure Immune System medicine.symptom |
| Zdroj: | Trends in Immunology. 38:705-718 |
| ISSN: | 1471-4906 |
| Popis: | The life of an organism requires the assistance of an unlikely process: programmed cell death. Indeed, both development and the maintenance of homeostasis results in the production of superfluous cells, that must eventually be disposed of. Furthermore, programmed cell death can also represent a defense mechanism, for example by depriving pathogens of a replication niche. The responsibility of handling these dead cells falls on phagocytes of the immune system, who surveil their surroundings for dying or dead cells and efficiently clear them in a quiescent manner. This process, termed efferocytosis, depends on cooperation between both the phagocyte and the dying cell. In this review, we explore different types of programmed cell death and their impact on innate immune responses. |
| Databáze: | OpenAIRE |
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