PD-L1 expression on monocytes marks active systemic lupus erythematosus in patients without nephritis
| Autor: | Jing-Ni Ou, Anne M. Stevens |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Autoimmune disease
medicine.medical_specialty lcsh:Diseases of the musculoskeletal system business.industry lcsh:RJ1-570 lcsh:Pediatrics medicine.disease Bioinformatics Rheumatology Proinflammatory cytokine Internal medicine Rheumatoid arthritis Pediatrics Perinatology and Child Health Immunology Follicular phase medicine Immunology and Allergy Oral Presentation In patient Pediatrics Perinatology and Child Health lcsh:RC925-935 business Nephritis Autoantibody production |
| Zdroj: | Pediatric Rheumatology Online Journal Pediatric Rheumatology Online Journal, Vol 10, Iss Suppl 1, p A2 (2012) |
| ISSN: | 1546-0096 |
| Popis: | Purpose Programmed death ligand 1 (PD-L1) plays an important role in controlling autoreactive and follicular T helper lymphocytes, which can induce autoantibody production. Properly expressed PD-L1 thus prevents autoimmune disease. Induced by inflammatory cytokines, PD-L1 is elevated on monocytes from patients with infections and rheumatoid arthritis, but is poorly expressed on monocytes from SLE patients with active disease. Our goal was to define the mechanism for PD-L1 dysregulation in pediatric patients with SLE, and to clinically characterize those patients with loss of PD-L1. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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