Umbilical cord PUFA are determined by maternal and child fatty acid desaturase (FADS) genetic variants in the Avon Longitudinal Study of Parents and Children (ALSPAC)

Autor: Norman Klopp, Joseph R. Hibbeln, Susan M. Ring, Sonja Zeilinger, Colin D Steer, Berthold Koletzko, Eva Lattka
Jazyk: angličtina
Rok vydání: 2012
Předmět:
Fatty Acid Desaturases
Male
medicine.medical_specialty
030309 nutrition & dietetics
Medicine (miscellaneous)
Polymorphism
Single Nucleotide
Umbilical cord
Article
Cohort Studies
03 medical and health sciences
chemistry.chemical_compound
Delta-5 Fatty Acid Desaturase
Fetus
Pregnancy
Fatty Acids
Omega-6
Internal medicine
Fatty Acids
Omega-3
medicine
Humans
Longitudinal Studies
Genetic Association Studies
030304 developmental biology
FADS
Fetal fatty acid supply
Cord blood
Avon Longitudinal Study of Parents and Children (ALSPAC)
chemistry.chemical_classification
Genetics
0303 health sciences
Nutrition and Dietetics
biology
Fatty acid metabolism
Fatty acid
Fetal Blood
medicine.disease
Fatty acid desaturase
medicine.anatomical_structure
Endocrinology
England
chemistry
Multigene Family
Multivariate Analysis
biology.protein
DNA
Intergenic
Female
Algorithms
Polyunsaturated fatty acid
Zdroj: British Journal of Nutrition
Br. J. Nutr. 109, 1196-1210 (2013)
ISSN: 1475-2662
0007-1145
DOI: 10.1017/S0007114512003108
Popis: Fetal supply with long-chain PUFA (LC-PUFA) during pregnancy is important for brain growth and visual and cognitive development and is provided by materno–fetal placental transfer. We recently showed that maternal fatty acid desaturase (FADS)genotypes modulate the amounts of LC-PUFA in maternal blood. WhetherFADSgenotypes influence the amounts of umbilical cord fatty acids has not been investigated until now. The aim of the present study was to investigate the influence of maternal and childFADSgenotypes on the amounts of LC-PUFA in umbilical cord venous plasma as an indicator of fetal fatty acid supply during pregnancy. A total of eleven cord plasman-6 andn-3 fatty acids were analysed for association with seventeenFADSgene cluster SNP in over 2000 mothers and children from the Avon Longitudinal Study of Parents and Children. In a multivariable analysis, the maternal genotype effect was adjusted for the child genotype and vice versa to estimate which of the two has the stronger influence on cord plasma fatty acids. Both maternal and childFADSgenotypes and haplotypes influenced amounts of cord plasma LC-PUFA and fatty acid ratios. Specifically, most analysed maternal SNP were associated with cord plasma levels of the precursorn-6 PUFA, whereas the child genotypes were mainly associated with more highly desaturatedn-6 LC-PUFA. This first study onFADSgenotypes and cord fatty acids suggests that fetal LC-PUFA status is determined to some extent by fetal fatty acid conversion. Associations of particular haplotypes suggest specific effects of SNP rs498793 and rs968567 on fatty acid metabolism.
Databáze: OpenAIRE
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