Long-term effects of Helicobacter pylori eradication in Mongolian gerbils
| Autor: | Fumihiro Hirayama, Eiji Iwao, Keiichiro Haga, Shiro Takagi, Yoshito Yokoyama, Katsuhiro Yamamoto |
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| Rok vydání: | 2002 |
| Předmět: |
Male
medicine.medical_specialty macromolecular substances Quinolones Gastroenterology Helicobacter Infections Anti-Infective Agents Clarithromycin Internal medicine medicine Gastric mucosa Animals Omeprazole Gastrin biology Helicobacter pylori business.industry Stomach Intestinal metaplasia medicine.disease biology.organism_classification Anti-Ulcer Agents Antibodies Bacterial digestive system diseases Anti-Bacterial Agents medicine.anatomical_structure Gastric Mucosa Gastritis Drug Therapy Combination medicine.symptom business Gerbillinae medicine.drug |
| Zdroj: | Journal of gastroenterology. 37(10) |
| ISSN: | 0944-1174 |
| Popis: | In this study, to clarify whether Helicobacter pylori eradication alters the course of the development of gastric mucosal changes in the stomach, we examined the long-term effects of H. pylori eradication on H. pylori-inoculated gerbils. Methods: A total of 40 H. pylori-inoculated gerbils were randomized and subjected, at 22 months after inoculation, to eradication treatment with dual therapy of omeprazole plus clarithromycin, or with therapy with a novel quinolone compound, Y-34867, alone. The animals were killed at the start of administration (control group) or at 8 months after the completion of therapy (vehicle or eradication-treatment groups). Results: Severe histopathological changes in the gastric mucosa were observed in all H. pylori-inoculated gerbils at the start of administration. At 8 months after completion of therapy, the frequency of gastritis, erosion, intestinal metaplasia, and gastric carcinoid in the eradication therapy groups was markedly reduced compared with that in the control and vehicle groups. Values for anti-H. pylori IgG titer, bacterial counts, and gastrin also decreased significantly. Conclusions: These results suggest that H. pylori eradication may have had a therapeutic effect not only on gastritis, erosion, and gastric ulcer but also on glandular atrophy, intestinal metaplasia, and gastric carcinoid. |
| Databáze: | OpenAIRE |
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