Combination of fasudil and celecoxib promotes the recovery of injured spinal cord in rats better than celecoxib or fasudil alone
| Autor: | Hua Yin, Xiaolin Hou, Duan Weigang, Yan Chen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Nervous system
Pharmacology lcsh:RC346-429 Developmental Neuroscience Medicine Rho kinase nerve regeneration NSFC grant Spinal cord injury Rho-associated protein kinase lcsh:Neurology. Diseases of the nervous system fasudil cyclooxygenase-2 celecoxib spinal cord injury neural regeneration business.industry Kinase Therapeutic effect Fasudil medicine.disease Spinal cord medicine.anatomical_structure Anesthesia Celecoxib business Research Article medicine.drug |
| Zdroj: | Neural Regeneration Research, Vol 10, Iss 11, Pp 1836-1840 (2015) Neural Regeneration Research |
| ISSN: | 1673-5374 |
| Popis: | Resistance mechanisms of rho-associated kinase (ROCK) inhibitors are associated with the enhanced expression of cyclooxygenase-2 (COX-2). The therapeutic effects of ROCK on nervous system diseases might be enhanced by COX-2 inhibitors. This study investigated the synergistic effect of the combined use of the ROCK inhibitor fasudil and a COX-2 inhibitor celecoxib on spinal cord injury in a rat model established by transecting the right half of the spinal cord at T 11 . Rat models were orally administrated with celecoxib (20 mg/kg) and/or intramuscularly with fasudil (10 mg/kg) for 2 weeks. Results demonstrated that the combined use of celecoxib and fasudil significantly decreased COX-2 and Rho kinase II expression surrounding the lesion site in rats with spinal cord injury, improved the pathomorphology of the injured spinal cord, and promoted the recovery of motor function. Moreover, the effects of the drug combination were better than celecoxib or fasudil alone. This study demonstrated that the combined use of fasudil and celecoxib synergistically enhanced the functional recovery of injured spinal cord in rats. |
| Databáze: | OpenAIRE |
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