Global gene expression profiling of hyperkeratotic skin lesions from inner Mongolians chronically exposed to arsenic
| Autor: | Kathryn Bailey, Judy L. Mumford, William O. Ward, Jinyao Mo, Russell D. Owen, Geremy Knapp, Yajuan Xia, Sheau-Fung Thai |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty China Hyperkeratoses Skin Neoplasms DNA Repair Hyperkeratosis Apoptosis Wnt1 Protein Biology Toxicology medicine.disease_cause Pathology and Forensic Medicine Arsenic Stress Physiological Gene expression Arsenic Poisoning medicine Cell Adhesion Humans Calcium Signaling Molecular Biology Gene Pathological Cytoskeleton beta Catenin Cell Proliferation Gene Expression Profiling Cell Differentiation Cell Biology Keratosis Middle Aged medicine.disease Dyskeratosis Gene expression profiling Gene Expression Regulation Carcinogens Female Mitogen-Activated Protein Kinases Carcinogenesis DNA Damage |
| Zdroj: | Toxicologic pathology. 37(7) |
| ISSN: | 1533-1601 |
| Popis: | The skin is an organ that is highly sensitive to chronic arsenic (As) exposure. Skin lesions such as hyperkeratoses (HKs) are common early manifestations of arsenicosis in humans. HKs can be precursor lesions of nonmelanoma skin cancers (NMSCs), but the driving forces behind their formation and how they may ultimately progress to NMSCs are unknown. The goal of this study was to examine the global gene expression profiles of As-related HKs in an effort to better understand gene expression changes that are potentially associated with early stages of As carcinogenesis. HK biopsies were removed from individuals living in an arsenicosis-endemic region in Inner Mongolia who had been exposed to high As levels in their drinking water for >20 years. Gene expression profiling was performed on RNA isolated from 7 individuals in this group and from 4 lesion-free skin samples from healthy individuals. Consistent with the pathological characteristics of the HK lesions, major functional categories and known canonical pathways represented by altered transcripts include those involved in development, differentiation, apoptosis, proliferation, and stress response. The results of this study may help define a signature profile of gene expression changes associated with long-term As exposure in the skin. |
| Databáze: | OpenAIRE |
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