Association of Serum Myostatin with Body Weight, Visceral Fat Volume, and High Sensitivity C-Reactive Protein But Not With Muscle Mass and Physical Fitness in Premenopausal Women
| Autor: | Stefanie Kern-Matschilles, Nina Hesse, Andreas Lechner, A Potzel, Cornelia Then, Stefanie J. Haschka, Jochen Seissler, Lorena Wanger, Christina Gar |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Diabetes risk Endocrinology Diabetes and Metabolism Myostatin Intra-Abdominal Fat Body fat percentage Body Mass Index Endocrinology Insulin resistance Pregnancy Internal medicine Myokine Internal Medicine Medicine Humans Insulin Metabolic Syndrome biology business.industry Muscles Body Weight General Medicine medicine.disease Gestational diabetes C-Reactive Protein Cross-Sectional Studies Physical Fitness biology.protein Female Metabolic syndrome Insulin Resistance business Body mass index |
| Zdroj: | Experimental and clinical endocrinologydiabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. 130(6) |
| ISSN: | 1439-3646 |
| Popis: | Background The myokine myostatin regulates muscle mass and has been linked to insulin resistance and metabolic syndrome. However, data on its role in humans is still limited. We, therefore, investigated the associations of serum myostatin with muscle mass, physical fitness, and components of the metabolic syndrome in a cohort of premenopausal women. Methods We undertook a cross-sectional analysis of 233 women from the monocenter study PPSDiab, conducted in Munich, Germany. Participants had recently completed a pregnancy with or without gestational diabetes. Our analysis included medical history, anthropometrics, oral glucose tolerance testing, laboratory chemistry, cardiopulmonary exercise testing, and magnetic resonance imaging (n=142) of visceral fat volume, left quadriceps muscle mass, and muscle fat content. Serum myostatin was quantified by a competitive enzyme-linked immunosorbent assay. Results We observed positive correlations of serum myostatin with body mass index (ρ=0.235; p=0.0003), body fat percentage (ρ=0.166; p=0.011), waist circumference (ρ=0.206; p=0.002), intraabdominal fat volume (ρ=0.182; p=0.030) and high-sensitivity C-reactive protein (ρ=0.175; p=0.008). These correlations were reproduced in linear regression analyses with adjustment for age and time after delivery. We saw no correlations with muscle mass, physical fitness, insulin sensitivity, triglycerides, HDL cholesterol, and blood pressure. Conclusions Our observation of elevated serum myostatin in women with a higher body fat percentage, visceral obesity, and elevated c-reactive protein suggests that this myokine contributes to the altered muscle-adipose tissue crosstalk in metabolic syndrome. Elevated myostatin may advance this pathophysiologic process and could also impair the efficacy of exercise interventions. Further mechanistic studies, therefore, seem warranted. |
| Databáze: | OpenAIRE |
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