Effects of morphine and alcohol on functional brain connectivity during 'resting state': A placebo-controlled crossover study in healthy young men
| Autor: | Najmeh Khalili-Mahani, J.M.A. van Gerven, Albert Dahan, ML de Kam, M.A. van Buchem, Serge A.R.B. Rombouts, E. Baerends, Roelof P. Soeter, Christian F. Beckmann, Rwm Zoethout |
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| Přispěvatelé: | Magnetic Detection and Imaging, Faculty of Science and Technology |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Research Donders Centre for Cognitive Neuroimaging
Male Aetiology screening and detection [ONCOL 5] METIS-292328 resting state networks dual regression IR-83007 Infusions Intravenous Research Articles media_common Brain Mapping Cross-Over Studies Radiological and Ultrasound Technology alcohol 220 Statistical Imaging Neuroscience Brain morphine Magnetic Resonance Imaging Neurology Anatomy Psychology medicine.drug Drug Adult Adolescent media_common.quotation_subject Rest resting state fMRI Placebo Young Adult Pharmacokinetics Double-Blind Method Post-hoc analysis medicine Humans Radiology Nuclear Medicine and imaging Resting state fMRI Ethanol functional connectivity Crossover study pharmaMRI Opioid Onderzoek Donders Centre for Cognitive Neuroimaging Pharmacodynamics opioid Neurology (clinical) Nerve Net pharmacology Neuroscience BOLD |
| Zdroj: | Human Brain Mapping, 33(5), 1003-1018 Hum Brain Mapp Human Brain Mapping Human Brain Mapping, 33, 1003-1018 Human brain mapping, 33(5), 1003-1018. Wiley-Liss Inc. Human Brain Mapping, 33, 5, pp. 1003-1018 |
| ISSN: | 1065-9471 |
| Popis: | Item does not contain fulltext A major challenge in central nervous system (CNS) drug research is to develop a generally applicable methodology for repeated measurements of drug effects on the entire CNS, without task-related interactions and a priori models. For this reason, data-driven resting-state fMRI methods are promising for pharmacological research. This study aimed to investigate whether different psychoactive substances cause drug-specific effects in functional brain connectivity during resting-state. In this double blind placebo-controlled (double dummy) crossover study, seven resting-state fMRI scans were obtained in 12 healthy young men in three different drug sessions (placebo, morphine and alcohol; randomized). Drugs were administered intravenously based on validated pharmacokinetic protocols to minimize the inter- and intra-subject variance in plasma drug concentrations. Dual-regression was used to estimate whole-brain resting-state connectivity in relation to eight well-characterized resting-state networks, for each data set. A mixed effects analysis of drug by time interactions revealed dissociable changes in both pharmacodynamics and functional connectivity resulting from alcohol and morphine. Post hoc analysis of regions of interest revealed adaptive network interactions in relation to pharmacokinetic and pharmacodynamic curves. Our results illustrate the applicability of resting-state functional brain connectivity in CNS drug research. Hum Brain Mapp, 2011. (c) 2011 Wiley-Liss, Inc. |
| Databáze: | OpenAIRE |
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