Cell source determines the immunological impact of biomimetic nanoparticles
| Autor: | Jonathan O. Martinez, Brandon S. Brown, Xuewu Liu, Nima Taghipour, Michael Evangelopoulos, Iman K. Yazdi, Nicoletta Quattrocchi, Christian Boada, Anne L. van de Ven, Ennio Tasciotti, Shilpa Scaria, Mauro Ferrari, Claudia Corbo, Alessandro Parodi, Armando Cevenini |
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| Přispěvatelé: | Evangelopoulos, Michael, Parodi, Alessandro, Martinez, Jonathan O., Yazdi, Iman K., Cevenini, Armando, van de Ven, Anne L., Quattrocchi, Nicoletta, Boada, Christian, Taghipour, Nima, Corbo, Claudia, Brown, Brandon S., Scaria, Shilpa, Liu, Xuewu, Ferrari, Mauro, Tasciotti, Ennio, Evangelopoulos, M, Parodi, A, Martinez, J, Yazdi, I, Cevenini, A, van de Ven, A, Quattrocchi, N, Boada, C, Taghipour, N, Corbo, C, Brown, B, Scaria, S, Liu, X, Ferrari, M, Tasciotti, E |
| Jazyk: | angličtina |
| Předmět: |
opsonization
leukocyte membrane Cell Biocompatible Materials animal cell 02 engineering and technology reactive oxygen metabolite Mice Nanoparticle aspartate aminotransferase Biomimetic Materials drug delivery system Macrophage cell interaction Leukolike Vector comparative study Cells Cultured tumor necrosis factor alpha Systemic administration creatinine biomimetic material Cell biology Antibody opsonization cytokine release priority journal nanocarrier 0210 nano-technology surface charge in vitro study Biocompatibility Biophysics Ceramics and Composite Bioengineering macrophage Article animal tissue in vivo study Biomaterials zeta potential 03 medical and health sciences Nanovector human protein expression mouse human cell Drug products Biological materials mononuclear phagocyte Immunity Innate Cell membranes 030104 developmental biology Immunology interleukin 1alpha Nanoparticles Comprehensive evaluation 0301 basic medicine interleukin 1beta immunology Bagg albino mouse Biomimetics Leukocytes nanocapsule animal Multistage nanovector innate immunity Immunological effects Mice Inbred BALB C Time-lapse microscopy phagocytosis 021001 nanoscience & nanotechnology unclassified drug medicine.anatomical_structure liver function Mechanics of Materials Drug delivery gamma interferon medicine.symptom leukocyte time lapse imaging alanine aminotransferase Antigen-antibody reactions animal experiment transcription factor RelA interleukin 6 Inflammation Biology interleukin 2 Nanocapsules interleukin 3 evaluation study medicine Biomimicry Animals controlled study Mechanics of Material Immunobiology cell culture nonhuman static electricity Biomaterial Biomimetic nanoparticles internalization 7 INGENIERÍA Y TECNOLOGÍA drug effects Ceramics and Composites interleukin 12 interleukin 10 |
| Zdroj: | Biomaterials |
| ISSN: | 0142-9612 |
| DOI: | 10.1016/j.biomaterials.2015.11.054 |
| Popis: | Recently, engineering the surface of nanotherapeutics with biologics to provide them with superior biocompatibility and targeting towards pathological tissues has gained significant popularity. Although the functionalization of drug delivery vectors with cellular materials has been shown to provide synthetic particles with unique biological properties, these approaches may have undesirable immunological repercussions upon systemic administration. Herein, we comparatively analyzed unmodified multistage nanovectors and particles functionalized with murine and human leukocyte cellular membrane, dubbed Leukolike Vectors (LLV), and the immunological effects that may arise in vitro and in vivo. Previously, LLV demonstrated an avoidance of opsonization and phagocytosis, in addition to superior targeting of inflammation and prolonged circulation. In this work, we performed a comprehensive evaluation of the importance of the source of cellular membrane in increasing their systemic tolerance and minimizing an inflammatory response. Time-lapse microscopy revealed LLV developed using a cellular coating derived from a murine (i.e., syngeneic) source resulted in an active avoidance of uptake by macrophage cells. Additionally, LLV composed of a murine membrane were found to have decreased uptake in the liver with no significant effect on hepatic function. As biomimicry continues to develop, this work demonstrates the necessity to consider the source of biological material in the development of future drug delivery carriers. © 2015. |
| Databáze: | OpenAIRE |
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