[18F]THK-5117 PET for assessing neurofibrillary pathology in Alzheimer’s disease
| Autor: | Ren Iwata, Kotaro Hiraoka, Yoichi Ishikawa, Rin Matsuda, Miho Shidahara, Aiko Ishiki, Ryuichi Harada, Tetsuro Tago, Kazuhiko Yanai, Nobuyuki Okamura, Masayasu Miyake, Manabu Tashiro, Yoshihito Funaki, Shoichi Watanuki, Akie Inami, Hiroyuki Arai, Shozo Furumoto, Yukitsuka Kudo, Naoki Tomita, Katsutoshi Furukawa, Takeo Yoshikawa |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Pathology medicine.medical_specialty Disease Temporal lobe Alzheimer Disease medicine Humans Dementia Radiology Nuclear Medicine and imaging Benzothiazoles Aged Aged 80 and over Cerebral Cortex Temporal cortex Aniline Compounds business.industry General Medicine Healthy elderly Highly selective medicine.disease In vitro binding Thiazoles Case-Control Studies Positron-Emission Tomography Neurofibrils Quinolines Female Radiopharmaceuticals business |
| Zdroj: | European Journal of Nuclear Medicine and Molecular Imaging. 42:1052-1061 |
| ISSN: | 1619-7089 1619-7070 |
| DOI: | 10.1007/s00259-015-3035-4 |
| Popis: | Visualization of the spatial distribution of neurofibrillary tangles would help in the diagnosis, prevention and treatment of dementia. The purpose of the study was to evaluate the clinical utility of [(18)F]THK-5117 as a highly selective tau imaging radiotracer.We initially evaluated in vitro binding of [(3)H]THK-5117 in post-mortem brain tissues from patients with Alzheimer's disease (AD). In clinical PET studies, [(18)F]THK-5117 retention in eight patients with AD was compared with that in six healthy elderly controls. Ten subjects underwent an additional [(11)C]PiB PET scan within 2 weeks.In post-mortem brain samples, THK-5117 bound selectively to neurofibrillary deposits, which differed from the binding target of PiB. In clinical PET studies, [(18)F]THK-5117 binding in the temporal lobe clearly distinguished patients with AD from healthy elderly subjects. Compared with [(11)C]PiB, [(18)F]THK-5117 retention was higher in the medial temporal cortex.These findings suggest that [(18)F]THK-5117 provides regional information on neurofibrillary pathology in living subjects. |
| Databáze: | OpenAIRE |
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