Characterization of the immunomodulatory and anti-Helicobacter pylori properties of the human gastric isolate Lactobacillus rhamnosus UCO-25A
| Autor: | Ana María Marín-Vega, Apolinaria García-Cancino, Valeria Garcia-Castillo, Leonardo Albarracin, Alejandra Ilabaca, Julio Villena, Guillermo Marcial, Haruki Kitazawa |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
CIENCIAS MÉDICAS Y DE LA SALUD 030106 microbiology Inmunología Aquatic Science Applied Microbiology and Biotechnology LACTOBACILLUS RHAMNOSUS Microbiology 03 medical and health sciences fluids and secretions Lactobacillus rhamnosus MACROPHAGES Water Science and Technology biology Chemistry Biofilm HELICOBACTER PYLORI food and beverages Helicobacter pylori biology.organism_classification GASTRIC EPITHELIAL CELLS UCO-25A Medicina Básica 030104 developmental biology BIOFILM GASTRIC INFLAMMATION LACTOBACILLUS RHAMNOSUS UCO-25A |
| Zdroj: | Biofouling. 35:922-937 |
| ISSN: | 1029-2454 0892-7014 |
| DOI: | 10.1080/08927014.2019.1675153 |
| Popis: | The ability to form biofilms and the potential immunomodulatory properties of the human gastric isolate Lactobacillus rhamnosus UCO-25A were characterized in vitro. It was demonstrated that L. rhamnosus UCO-25A is able to form biofilms on abiotic and cell surfaces, and to modulate the inflammatory response triggered by Helicobacter pylori infection in gastric epithelial cells and THP-1 macrophages. L. rhamnosus UCO-25A exhibited a substantial antiinflammatory effect in both cell lines and improved IL-10 levels produced by challenged macrophages. Additionally, UCO-25A protected AGS cells against H. pylori infection with a higher pathogen inhibition when a biofilm was formed. Given the importance of inflammation in H. pylori-mediated diseases, the differential modulation of the inflammatory response in the gastric mucosa by an autochthonous strain is an attractive alternative for improving H. pylori eradication and reducing the severity of the diseases that arise from the resulting chronic inflammation. Fil: Garcia Castillo, Valeria. Universidad de Concepción; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Tohoku University; Japón Fil: Marín Vega, Ana María. Tohoku University; Japón Fil: Ilabaca, Alejandra. Universidad de Concepción; Chile Fil: Albarracín, Leonardo Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Tohoku University; Japón. Universidad Nacional de Tucumán. Facultad de Ciencias Exactas y Tecnología; Argentina Fil: Marcial, Guillermo Emilio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina Fil: Kitazawa, Haruki. Tohoku University; Japón Fil: Garcia Cancino, Apolinaria. Tohoku University; Japón Fil: Villena, Julio Cesar. Tohoku University; Japón. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina |
| Databáze: | OpenAIRE |
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