Is there a Need for Luteinizing Hormone (LH) Estimation in Patients Undergoing Ovarian Stimulation with Gonadotropin-Releasing Hormone (GnRH) Antagonists and Recombinant Follicle-Stimulating Hormone (rFSH)?
| Autor: | Pratap Kumar, Amar Ramachandran, Rajeshwari G Bhat, Sinatra R. Ferrao, Satish Kumar Adiga, Kshitij P. Jamdade |
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| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
endocrine system Recombinant Follicle Stimulating Hormone media_common.quotation_subject Clinical Biochemistry lcsh:Medicine Stimulation Gonadotropin-releasing hormone gonadotropin releasing hormone (gnrh) antagonist Andrology Human fertilization Internal medicine medicine In patient Ovulation reproductive and urinary physiology media_common business.industry urogenital system lcsh:R Antagonist General Medicine Endocrinology embryonic structures luteinizing hormone recombinant follicle stimulating hormone (rfsh) Original Article Luteinizing hormone business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Journal of Clinical and Diagnostic Research, Vol 8, Iss 1, Pp 90-92 (2014) |
| ISSN: | 2249-782X |
| Popis: | Aim: To find out effect of serum luteinizing hormone (LH) levels on Day 1 (Day 2 of cycle) and Day 5 of stimulation and Day of trigger hCG in controlled ovulation stimulation with antagonist protocol of IVF-ICSI cycle on cycle outcome. Materials and Methods: This retrospective study was conducted in a University Hospital setting. One hundred and 62 patients underwent 165 cycles of controlled ovarian stimulation (COS) with recombinant Follicle stimulating hormone (rFSH) and Gonadotropin releasing hormone (GnRH) antagonist protocol in one year were included. Serum LH levels estimated on Day 1, Day 5 and the day of trigger hCG injections were divided into three groups based on the percentile and outcome measured. Results: The average number of follicles >18 mm in size were significant in the patients with LH levels between 25th to 75th percentile group on Day 1, Day 5 and Day of trigger hCG. The fertilization rate was significant (p= 0.04) in the patients with LH levels < 25thpercentile on the day of trigger hCG. Oocyte recovery rate, oocyte maturation rate and average number of best quality embryos (Grade 1) were not affected significantly in all three groups. Conclusion: In GnRH antagonist and rFSH protocols, low serum LH concentrations on the day of trigger hCG has better fertilization rate. LH levels between 25th and 75th percentile have an influence on the average number of > 18 mm size follicles. However, the LH level on Day 1, Day 5 and Day of hCG does not affect the cycle outcome in COS with antagonist protocol of IVF cycle. Hence, LH estimation is not mandatory in ART cycles with GnRH antagonist protocol. |
| Databáze: | OpenAIRE |
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