Osteosarcoma and chondrosarcoma of the maxilla
| Autor: | Anshul Jain, Naresh K. Panda, C. Ekambar E. Reddy |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Chondrosarcoma India Trismus Sex Factors medicine Humans Neoplasm Invasiveness Child Aged Neoplasm Staging Retrospective Studies Maxillary Neoplasms Osteosarcoma business.industry Osteoid Age Factors Anatomy Middle Aged medicine.disease Surgery Survival Rate Skull medicine.anatomical_structure Otorhinolaryngology Maxilla Female Sarcoma Hard palate Oral Surgery medicine.symptom business Follow-Up Studies |
| Zdroj: | The British journal of oralmaxillofacial surgery. 41(5) |
| ISSN: | 0266-4356 |
| Popis: | The mean age at presentation was 27 years (range 9–65) with equal sex distribution and half were under 20 years of age (Table 1). Presenting features were rapidly progressive cheek swelling (n = 11), facial pain (n = 6), mass in the hard palate (n = 5), previous dental extraction (n = 5), nasal obstruction (n = 4), proptosis (n = 4), reduction in vision (n = 2), trismus (n = 2), and epistaxis (n = 1). The duration of symptoms varied from 2 weeks to 3 months. Computed tomoscans (CT) were available for 10 of them, and findings varied from predominantly radiolucent, poorly delineated lesions to dense, radio-opaque masses with a sunburst appearance (Fig. 1). Extension to the orbit (n = 4), destruction of the septum with extension to the opposite side (n = 3) and involvement of the skull base (n = 2) were noted. Using AJCC classification they belonged to stage III (n = 6) and stage IV (n = 6). Histological examination showed areas of sarcomatous stroma with direct production of tumour osteoid and bone from malignant connective tissue. The stroma of the tumour was typically composed of anaplastic spindle cells with hyperchromatic nuclei and tumour foci at the periphery of the specimen that were poorly mineralised. Resection with postoperative radiotherapy was the mainstay of treatment (n = 9), resection alone was done in one child, and palliative resection with chemotherapy (n = 2) using cyclophosphamide, vincristine and doxorubicin was administered. Palliative resection was done because both of them had involvement of the skull base. Mean follow-up was 29 months (range 4 months to 6 years). Two patients were lost to follow-up at 4 months and 41/2 years, respectively, 5 were alive without recurrence, and 5 died of local disease or pulmonary metastases. The cumulative probability of 5-year survival calculated by Kaplan–Meier method was almost nil. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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