Genome-wide association study identified SNP on 15q24 associated with bladder cancer risk in Japanese population
| Autor: | Debra T. Silverman, Kenjiro Kohri, Chizu Tanikawa, Ichiro Yamasaki, Hiromi Kumon, Koichi Matsuda, Ri Cui, Ludmila Prokunina-Olsson, Jonine D. Figueroa, Yusuke Nakamura, Atsushi Takahashi, Candace D. Middlebrooks, Wataru Obara, Yoshio Naya, Yasutomo Nasu, Masayuki Nakagawa, Michiaki Kubo, Kenji Tamura, Tsuneharu Miki, Mikio Namiki, Taro Shuin, Hiroyuki Nishiyama, Tomoaki Fujioka, Nathaniel Rothman, Masayoshi Yokoyama, Yoshihiko Tomita, Keiji Inoue, Takashi Deguchi |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Linkage disequilibrium Candidate gene Genotype Single-nucleotide polymorphism Genome-wide association study Biology Polymorphism Single Nucleotide Asian People Japan Odds Ratio Genetics medicine Humans Genetic Predisposition to Disease Molecular Biology Allele frequency Alleles Genetic Association Studies Genetics (clinical) Genetic association Chromosomes Human Pair 15 Bladder cancer Association Studies Articles Smoking Reproducibility of Results Cancer General Medicine medicine.disease Urinary Bladder Neoplasms Case-Control Studies Female Genome-Wide Association Study |
| Zdroj: | Human Molecular Genetics. 24:1177-1184 |
| ISSN: | 1460-2083 0964-6906 |
| Popis: | Through genome-wide association analysis and an independent replication study using a total of 1131 bladder cancer cases and 12 558 non-cancer controls of Japanese populations, we identified a susceptibility locus on chromosome 15q24. SNP rs11543198 was associated with bladder cancer risk with odds ratio (OR) of 1.41 and P-value of 4.03 × 10(-9). Subgroup analysis revealed rs11543198 to have a stronger effect in male smokers with OR of 1.66. SNP rs8041357, which is in complete linkage disequilibrium (r(2) = 1) with rs11543198, was also associated with bladder cancer risk in Europeans (P = 0.045 for an additive and P = 0.025 for a recessive model), despite much lower minor allele frequency in Europeans (3.7%) compared with the Japanese (22.2%). Imputational analysis in this region suggested CYP1A2, which metabolizes tobacco-derived carcinogen, as a causative candidate gene. We also confirmed the association of previously reported loci, namely SLC14A1, APOBEC3A, PSCA and MYC, with bladder cancer. Our finding implies the crucial roles of genetic variations on the chemically associated development of bladder cancer. |
| Databáze: | OpenAIRE |
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