3D Printed 'Starmix' Drug Loaded Dosage Forms for Paediatric Applications
| Autor: | Steven A. Ross, Nicolaos Scoutaris, Dennis Douroumis |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
business.product_category
Materials science Drug Compounding Indomethacin education Administration Oral Pharmaceutical Science Excipient 02 engineering and technology Polyethylene glycol Methylcellulose 030226 pharmacology & pharmacy Dosage form Polyethylene Glycols Excipients 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Differential scanning calorimetry PEG ratio Bottle medicine Humans QD Pharmacology (medical) Dissolution testing Child Pharmacology Anti-Inflammatory Agents Non-Steroidal Organic Chemistry Taste Perception 021001 nanoscience & nanotechnology Drug Liberation Chemical engineering chemistry Taste Printing Three-Dimensional Feasibility Studies Molecular Medicine Extrusion 0210 nano-technology business Tablets Biotechnology medicine.drug |
| Zdroj: | Pharmaceutical Research. 35 |
| ISSN: | 1573-904X 0724-8741 |
| Popis: | Purpose:\ud Three- dimensional (3D) printing has received significant attention as a manufacturing process for pharmaceutical dosage forms. In this study, we used Fusion Deposition Modelling (FDM) in order to print "candy - like" formulations by imitating Starmix sweets to prepare paediatric medicines with enhanced palatability. Methods Hot melt extrusion processing (HME) was coupled with FDM to prepare extruded filaments of indomethacin (IND), hypromellose acetate succinate (HPMCAS) and polyethylene glycol (PEG) formulations and subsequently feed them in the 3D printer. The shapes of the Starmix objects were printed in the form of a heart, ring, bottle, ring, bear and lion. Differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD), Fourier Transform Infra-red Spectroscopy (FT-IR) and confocal Raman analysis were used to assess the drug - excipient interactions and the content uniformity.\ud \ud Results:\ud Physicochemical analysis showed the presence of molecularly dispersed IND in the printed tablets. In vivo taste masking evaluation demonstrated excellent masking of the drug bitterness. The printed forms were evaluated for drug dissolution and showed immediate IND release independently of the printed shape, within 60min.\ud \ud Conclusions:\ud 3D printing was used successfully to process drug loaded filaments for the development of paediatric printed tablets in the form of Starmix designs. |
| Databáze: | OpenAIRE |
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