[Evaluation of fine needle aspiration cytology in the diagnosis of cancer of the parotid gland]
| Autor: | Paola Aranda Valderrama, Carlos Andrés García, Julio Alexander Díaz Pérez, Álvaro Antonio Herrera Hernández, Loren Paola Herrera, Luis Carlos Orozco Vargas |
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| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty Population Biopsy Fine-Needle Malignancy Surgical pathology Diagnosis Differential medicine Carcinoma Humans education education.field_of_study medicine.diagnostic_test business.industry General Medicine Gold standard (test) Middle Aged medicine.disease Parotid gland Parotid Neoplasms body regions Fine-needle aspiration medicine.anatomical_structure Histopathology Female Radiology business |
| Zdroj: | Acta otorrinolaringologica espanola. 59(5) |
| ISSN: | 0001-6519 |
| Popis: | Background Fine needle aspiration (FNA) is commonly used in the study of neoplastic lesions of the parotid gland, however controversy exists regarding its diagnostic accuracy. Objective To evaluate the performance of FNA biopsy as compared to open surgical biopsy in the diagnosis of carcinoma of the parotid gland. Material and method Forty-six patients with parotid masses from 7 health centres in Bucaramanga, Colombia, were identified and included in the study. All patients underwent FNA and open surgical biopsy, with the latter considered the diagnostic gold standard. The FNA and final surgical histopathology were interpreted as either positive or negative for malignancy by pathologists blinded to the FNAoutcome. Only standard histological stains were used. The data were compared in a contingency table and analyzed statistically to determine the accuracy of FNA to predict the surgical pathology according to standard measures. Results The mean age of patients was 52 (16) years old and 59% were female. Using FNA, 18% of the initial diagnoses were found to be erroneous at final pathology. FNA had a sensitivity of 0.54, a specificity of 0.90, a PPV of 0.70, an NPV of 0.83, an LR + of 5.92, an LR– of 0.5, and kappa of 0.48 in the identification of parotid gland carcinoma from referral population with a disease prevalence of 28.3%. Conclusions In line with other previous studies, FNAbiopsy alone was unreliable to diagnose parotid gland carcinoma. Its low sensitivity and LR– indicates its limitations as a screening test; in addition its low kappa shows a modest correlation to the eventual diagnosis. Therefore, further critical examination of techniques and interpretation of parotid FNA are recommended. The development of new methods allowing a valid and precise diagnosis of this pathology and that, like the FNA, have low cost and ease of application is recommended. |
| Databáze: | OpenAIRE |
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