Hypoglycaemic and hypolipidaemic effects of crude extracts and chromatographic fractions of Morinda morindoides root bark in diabetic rats
| Autor: | MO Abatan, Timothy Adeolu Amusan, J. O. Olukunle, O.T. Adenubi |
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| Rok vydání: | 2012 |
| Předmět: |
lcsh:Veterinary medicine
Chromatography Chloroform General Veterinary Ethyl acetate Fractionation lipid lowering Glibenclamide chemistry.chemical_compound High-density lipoprotein Antidiabetic chemistry Distilled water visual_art Low-density lipoprotein visual_art.visual_art_medium medicine lcsh:SF600-1100 Bark medicinal plants medicine.drug |
| Zdroj: | Acta Veterinaria Brno, Vol 81, Iss 3, Pp 269-274 (2012) |
| ISSN: | 1801-7576 0001-7213 |
| DOI: | 10.2754/avb201281030269 |
| Popis: | Hypoglycaemic and hypolipidaemic effects of different extracts and fractions of root bark from the plantMorinda morindoides(Baker) Milne-Redh of the familyRubiaceaewere evaluated in alloxan-induced diabetic rats. The aqueous and methanolic extracts were administered to 48 rats orally at a dose of 400 mg·kg-1for 21 days.Fractions (hydromethanol, hexane, chloroform and ethyl acetate) from bio-activity guided fractionation and chromatographic sub fractions (CsF) A-F from accelerated gradient chromatography were also evaluated in 45 rats for the hypoglycaemic activity at doses of 400 mg·kg-1, 200 mg·kg-1and 100 mg·kg-1of solvent fractions and (CsF) A-F, respectively. Glibenclamide was used as positive control. Polyoxyethylene sorbitan monooleate and distilled water administered to rats were used as negative controls. The dose of 400 mg·kg-1of aqueous and methanolic extracts and 100 mg·kg-1of chloroformCsFB ofMorinda morindoidescaused (62.8%, 56% and 74%, respectively) reductions in blood glucose level (BGL). The aqueous extract caused significant (P< 0.05) decreases in the values of serum cholesterol (133.48 ± 1.1) mg·dl-1, low density lipoprotein (66.38 ± 2.5) mg·dl-1and significant (P< 0.05) increase in the value of high density lipoprotein (51.03 ± 3.0) mg·dl-1when compared to the control. These results confirm the folkloric claim of the hypoglycaemic and hypolipidaemic activities ofMorinda morindoidesroot bark. |
| Databáze: | OpenAIRE |
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