Chromosome 1q21.2 and additional loci influence risk of spontaneous coronary artery dissection and myocardial infarction

Autor:	Liam R. Brunham, Chad M. Brummett, Natalia Fendrikova-Mahlay, Million Veteran Program, Chang Xu, Christopher J. O'Donnell, Catherine Tcheandjieu, Kristina L. Hunker, Ellen M. Schmidt, Kirby Swan, Jacqueline Saw, Heather L. Gornik, Themistocles L. Assimes, Dawn M. Coleman, Sebastian Zoellner, Mark Trinder, Isabelle Birt, Jun Li, Xiang Zhou, Andrew Starovoytov, Michael R. Mathis, Santhi K. Ganesh, Min-Lee Yang, Alexander Katz, Linda A. Jackson, James C. Stanley, Matthew Zawistowski
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	0301 basic medicine Carotid Artery Diseases Male Coronary Vessel Anomalies Myocardial Infarction General Physics and Astronomy 02 engineering and technology Fibromuscular dysplasia Coronary Artery Disease Coronary artery disease Cohort Studies ADAMTS Proteins Risk Factors Fibromuscular Dysplasia Myocardial infarction Genetic risk lcsh:Science Multidisciplinary Microfilament Proteins 021001 nanoscience & nanotechnology Cardiology Female 0210 nano-technology Low Density Lipoprotein Receptor-Related Protein-1 medicine.medical_specialty Science Lower risk General Biochemistry Genetics and Molecular Biology Article Chromosomes 03 medical and health sciences Meta-Analysis as Topic Internal medicine medicine Humans Vascular Diseases Artery dissection business.industry Chromosome General Chemistry Cardiovascular genetics medicine.disease Computational biology and bioinformatics 030104 developmental biology lcsh:Q Scad business Genes Neoplasm Genome-Wide Association Study
Zdroj:	Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020) Nature Communications
ISSN:	2041-1723
Popis:	Spontaneous coronary artery dissection (SCAD) is a non-atherosclerotic cause of myocardial infarction (MI), typically in young women. We undertook a genome-wide association study of SCAD (Ncases = 270/Ncontrols = 5,263) and identified and replicated an association of rs12740679 at chromosome 1q21.2 (Pdiscovery+replication = 2.19 × 10−12, OR = 1.8) influencing ADAMTSL4 expression. Meta-analysis of discovery and replication samples identified associations with P Spontaneous coronary artery dissection (SCAD) is a cause of myocardial infarction Here, the authors present a genome-wide association study of SCAD, finding an association at 1q21.2 which potentially affects expression of ADAMTSL4.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::576e858e94528d650da5bf45f908ae67 http://link.springer.com/article/10.1038/s41467-020-17558-x Zobrazit plný text záznamu