Use of Contrast-Enhanced Ultrasound Sonography in Giant Cell Arteritis: A Proof-of-Concept Study
| Autor: | Jan Splitthoff, Raoul Bergner, Daniel Wadsack |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
Acoustics and Ultrasonics
Giant Cell Arteritis Biophysics Contrast Media Lumen (anatomy) Sensitivity and Specificity medicine Humans Radiology Nuclear Medicine and imaging Arteritis skin and connective tissue diseases Ultrasonography Radiological and Ultrasound Technology medicine.diagnostic_test business.industry Ultrasound Blood flow medicine.disease Giant cell arteritis C-Reactive Protein Erythrocyte sedimentation rate cardiovascular system business Nuclear medicine Perfusion Contrast-enhanced ultrasound |
| Zdroj: | Ultrasound in Medicine & Biology. 48:143-148 |
| ISSN: | 0301-5629 |
| DOI: | 10.1016/j.ultrasmedbio.2021.09.019 |
| Popis: | C-Reactive protein and erythrocyte sedimentation rate are crucial parameters used to monitor giant cell arteritis (GCA). Given that tocilizumab is approved for the treatment of GCA, these parameters are less sensitive because of the effects of interleukin-6 receptor blockade. Thus, the optimal method for monitoring GCA patients undergoing tocilizumab therapy, especially patients exhibiting a persistent thickened vessel wall in large vessels, remains unclear. Contrast-enhanced ultrasonography (CEUS) can increase the visibility of tissue perfusion by slow blood flow, which cannot be detected by power color doppler. We used CEUS to investigate patients with active and inactive GCA of the large vessels (active large vessel arteritis [aLVV]/inactive large vessel arteritis [iLVV]) who were not administered tocilizumab in this proof-of-concept study. After injection of the ultrasound contrast agent, the contrasted area (CA) of large vessels in a transverse section was calculated twice: first when the lumen was contrasted completely and once again 4–8 s later. We investigated the value of increase in CA that exhibited the best sensitivity and specificity for aLVV. Twenty-four patients were included in this study: 15 with aLVV and 9 with iLVV. The CA increased from 32.2 ± 16.8 to 52.5 ± 21.3 mm2 (p |
| Databáze: | OpenAIRE |
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