The Cause of Coagulopathy After Peritoneovenous Shunt for Malignant Ascites
| Autor: | John J. Gleysteen, Clara V. Hussey, Margaret G. Heckman |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Adult
Male Peritoneovenous Shunt medicine.medical_specialty medicine.medical_treatment Hematocrit Fibrin Fibrinogen Degradation Products Neoplasms Fibrinolysis Ascites Coagulopathy Humans Medicine Aged Aged 80 and over Prothrombin time medicine.diagnostic_test Platelet Count business.industry Antithrombin Fibrinogen Blood Coagulation Disorders Middle Aged medicine.disease Surgery Peritoneovenous shunt Prothrombin Time Female Partial Thromboplastin Time medicine.symptom business medicine.drug Partial thromboplastin time |
| Zdroj: | Archives of Surgery. 125:474 |
| ISSN: | 0004-0010 |
| DOI: | 10.1001/archsurg.1990.01410160060013 |
| Popis: | • Thirty-five patients with malignant ascites who received a peritoneovenous shunt were studied to determine the type and duration of postoperative coagulopathy. Coagulation factors were measured before and on the first and third day after the placement of a Denver peritoneovenous shunt; 1 to 10 L of ascites was removed at operation. Levels of platelets, antithrombin III, plasminogen, antiplasmin, fibrinogen, and factors V and VIII decreased by the first postoperative day but did not change further through the third day. The levels of fibrinolytic split products increased on day 1 but were lower by day 3. The platelet count reduction by the third day correlated with the hematocrit change (-0.031). The prothrombin and activated partial thromboplastin times remained normal postoperatively. The patterns of change were similar for patients with positive (n=18) and negative (n = 17) ascites cytologic findings, with elevated (n = 24) and normal (n = 11) preoperative fibrinolytic split product levels, an elevated bilirubin value (25 μmol/L; n=9), and no jaundice (n = 26). Bleeding did not occur. The data indicated that plasminogen- rather than thromboplastin-activated fibrinolysis occurred and that platelet reduction was largely dilutional. The reactions were not progressive when ascites was removed operatively. ( Arch Surg . 1990;125:474-477) |
| Databáze: | OpenAIRE |
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