SARS-CoV-2: From the pathogenesis to potential anti-viral treatments
| Autor: | Maryam Zinatizadeh, Mohammad Hadi Yousefi, Nima Rezaei, Peyman Kheirandish Zarandi, Mohammad Reza Zinatizadeh |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
viruses Review Disease Pathogenesis RM1-950 Favipiravir Cytokine storm Antiviral Agents Virus 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine MERS Humans Medicine Anti-viral treatments Darunavir SARS Pharmacology Clinical Trials as Topic business.industry SARS-CoV-2 Ribavirin COVID-19 virus diseases Lopinavir Hydroxychloroquine General Medicine medicine.disease COVID-19 Drug Treatment Treatment Outcome 030104 developmental biology chemistry 030220 oncology & carcinogenesis Immunology Therapeutics. Pharmacology business medicine.drug |
| Zdroj: | Biomedicine & Pharmacotherapy Biomedicine & Pharmacotherapy, Vol 137, Iss, Pp 111352-(2021) |
| ISSN: | 0753-3322 |
| DOI: | 10.1016/j.biopha.2021.111352 |
| Popis: | Introduction The world is witnessing the spread of one of the members of Coronaviruses (CoVs) family, called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the 21st century. Considering the short time spent after its prevalence, limited information is known about the effect of the virus mechanism on different organs of the body; meanwhile the lack of specific treatment and vaccine for this virus has exposed millions of people to a big challenge. Areas covered The review article aims to describe the general and particular characteristics of CoVs, their classification, genome structure, host cell infection, cytokine storm, anti-viral treatments, and inhibition of COVID-19-related ER-mitochondrial stress. In addition, it refers to drugs such as Chloroquine/Hydroxychloroquine, Lopinavir/Ritonavir, darunavir, ribavirin, remdesivir, and favipiravir, which have undergone clinical trials for coronavirus disease 2019 (COVID-19) treatment. This analysis was derived from an extensive scientific literature search including Pubmed, ScienceDirect, and Google Scholar performed. Expert opinion The effectiveness rate and complications of these drugs can reveal new insights into the potential therapeutic goals for the disease. Moreover, lifestyle change can effectively prevent SARS-CoV-2 infection. Graphical Abstract ga1 |
| Databáze: | OpenAIRE |
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