Expanding the Toolbox and Targets for Gene Editing
| Autor: | Sebastian Memczak, Jiameng Dan, Juan Carlos Izpisua Belmonte |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Gene Editing Mitochondrial DNA Nuclear gene Genome Computational biology Genetic Therapy Biology Toolbox Translational Research Biomedical 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Genome editing Genome Mitochondrial Molecular Medicine CRISPR Animals Humans Clustered Regularly Interspaced Short Palindromic Repeats CRISPR-Cas Systems Molecular Biology 030217 neurology & neurosurgery |
| Zdroj: | Trends in molecular medicine. 27(3) |
| ISSN: | 1471-499X |
| Popis: | Genome editing holds great promise for treating a range of human genetic diseases. While emerging clustered regularly interspaced short-palindromic repeats (CRISPR) technologies allow editing of the nuclear genome, it is still not possible to precisely manipulate mitochondrial DNA (mtDNA). Here, we summarize past developments and recent advances in nuclear and mitochondrial genome editing. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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