DOES FLOW-MEDIATED DILATION NORMALIZATION FOR BASE-SCALED SHEAR RATE IMPROVE ITS VALUE IN CORONARY ARTERY DISEASE DIAGNOSTICS?
| Autor: | Barbara Gambin, Robert Olszewski, Andrzej Nowicki, Z. Trawiński, Michal Szubielski, Wojciech Secomski |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Normalization (statistics) medicine.medical_specialty Acoustics and Ultrasonics Group ii Biophysics Flow mediated dilation 030209 endocrinology & metabolism Coronary Artery Disease 030204 cardiovascular system & hematology Coronary artery disease 03 medical and health sciences 0302 clinical medicine medicine.artery Internal medicine Stable cad medicine Humans Radiology Nuclear Medicine and imaging cardiovascular diseases Radial artery Aged Radiological and Ultrasound Technology business.industry Blood Pressure Determination Ultrasonography Doppler Cuff inflation Middle Aged medicine.disease Vasodilation Shear rate Regional Blood Flow Radial Artery Cardiology Female business |
| Zdroj: | Ultrasound in Medicine & Biology. 46:2551-2555 |
| ISSN: | 0301-5629 |
| DOI: | 10.1016/j.ultrasmedbio.2020.05.018 |
| Popis: | The article presents a new normalization of flow-mediated dilation (FMD) in the radial artery, taking into account the parameter BSSR being equal to the ratio of the basal shear rate (BS) measured before the cuff inflation and post occlusive shear rate (SR). The in vivo usefulness of the new normalization algorithm was evaluated in two groups of patients. In group I, comprising 15 healthy volunteers, the normalized FMD/SR was (3.19 ± 1.4)•10-4, while in group II, comprising 13 patients with stable coronary artery disease (CAD), it was (1.02 ± 0.76)•10-4. We calculated almost 50% larger difference between the average values after normalizing FMD/BSSR. Specifically, the FMD/BSSR was equal to 28 ± 9.40 in group I and 6.01 ± 3.74 in group II. The prediction of CAD patients based on FMD/SR values had a sensitivity of 83.3% and a specificity of 84.6%, whereas the prediction of CAD patients based on the FMD/BSSR values revealed 100% sensitivity and specificity. These results confirm the usefulness of the novel normalization algorithm of the FMD in differentiation of normal patients from those with stable CAD. |
| Databáze: | OpenAIRE |
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