Vitamin D, vitamin D binding protein, lung function and structure in COPD
| Autor: | Erica P.A. Rutten, Jane L. Meza, Corrine Hanson, Emiel F.M. Wouters, Lisa D. Edwards, Elisabeth A. P. M. Romme, Stephen I. Rennard, Debra J. Romberger, William MacNee, Isaac Berg, Harlan Sayles, Jørgen Vestbo, Amy Nelson, Bruce E. Miller |
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| Přispěvatelé: | Pulmonologie, RS: CAPHRI School for Public Health and Primary Care, RS: NUTRIM - R3 - Chronic inflammatory disease and wasting |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Pulmonary and Respiratory Medicine
Adult Male medicine.medical_specialty Pathology Vitamin D-binding protein medicine.drug_class Pilot Projects Walking Severity of Illness Index FEV1 Pulmonary Disease Chronic Obstructive Internal medicine Bronchodilator Forced Expiratory Volume medicine Vitamin D and neurology Humans Longitudinal Studies Vitamin D Lung function Asthma Aged Emphysema COPD 25(OH)D business.industry Surrogate endpoint Vitamin D-Binding Protein Middle Aged respiratory system medicine.disease Vitamin D Deficiency Bronchodilator Agents respiratory tract diseases Endocrinology Clara Cell Secretory Protein Pulmonary Emphysema Free vitamin D Female business Biomarkers circulatory and respiratory physiology |
| Zdroj: | Respiratory Medicine, 107(10), 1578-1588. Elsevier Saunders Berg, I, Hanson, C, Sayles, H, Romberger, D, Nelson, A, Meza, J, Miller, B, Wouters, E F M, Macnee, W, Rutten, E P A, Romme, E A P M, Vestbo, J, Edwards, L & Rennard, S 2013, ' Vitamin D, vitamin D binding protein, lung function and structure in COPD ', Respiratory Medicine, vol. 107, no. 10, pp. 1578-1588 . https://doi.org/10.1016/j.rmed.2013.05.010 |
| ISSN: | 0954-6111 |
| DOI: | 10.1016/j.rmed.2013.05.010 |
| Popis: | Rationale Vitamin D and vitamin D binding protein (DBP) have been associated with COPD and FEV1. There are limited data regarding emphysema and vitamin D and DBP. Objective This is a pilot study of a portion of the subjects in the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) study designed to examine the relationship between vitamin D status, DBP, FEV1 and emphysema in COPD patients. Methods We measured serum 25(OH)D and DBP in 498 ECLIPSE subjects. Subjects were distributed amongst smoker controls, non-smoker controls, and GOLD stages 2, 3 and 4. Within each GOLD stage, the subjects were equally divided amongst high and low emphysema burden. The associations between 25(OH)D, DBP, and free vitamin D with FEV1, CT-defined emphysema, biomarkers and clinical data including CT-measured bone attenuation were assessed. Measurements 25(OH)D and DBP were measured using tandem mass spectroscopy and competitive enzyme-linked immunosorbent assay, respectively, Main result 25(OH)D was correlated with FEV1 (p = 0.01) and with severity of emphysema (p < 0.01). 25(OH)D was also associated with six-minute walk (p = 0.02), bronchodilator response (p = 0.04), and Clara cell secretory protein (CC-16) (p = 0.01). 25(OH)D levels were not associated with CT-measured bone attenuation, however DBP was associated with bone attenuation in subjects with emphysema. DBP was not associated with FEV1 or emphysema. 25(OH)D and DBP were inversely associated (p = 0.01). Conclusion This is the first study to demonstrate a relationship between emphysema and vitamin D. We also provide further evidence for a relationship between vitamin D and FEV1. |
| Databáze: | OpenAIRE |
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