Fungal Liver Infection in Marrow Transplant Recipients: Prevalence at Autopsy, Predisposing Factors, and Clinical Features
| Autor: | Joel D. Meyers, LD Fisher, George B. McDonald, W. G. Meyer, David Myerson, Raleigh A. Bowden, Howard M. Shulman, George E. Sale, H. G. Schoch, Robert C. Hackman, F. Rossetti, D. L. Brawner |
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| Rok vydání: | 1995 |
| Předmět: |
Adult
Microbiology (medical) Pathology medicine.medical_specialty Hepatic veno-occlusive disease Autopsy Sensitivity and Specificity Gastroenterology Risk Factors Internal medicine Prevalence Humans Medicine Risk factor Mycosis Bone Marrow Transplantation Retrospective Studies Liver infection business.industry Liver Diseases medicine.disease Causality Transplantation Infectious Diseases Graft-versus-host disease Mycoses Multivariate Analysis business Complication |
| Zdroj: | Clinical Infectious Diseases. 20:801-811 |
| ISSN: | 1537-6591 1058-4838 |
| DOI: | 10.1093/clinids/20.4.801 |
| Popis: | To determine the prevalence of fungal liver infection at autopsy in marrow transplant recipients, we reviewed autopsy results for the period 1980-1989. Cases were compared to randomly chosen autopsied controls without fungal infection. Fungal liver infection was found in 67 (9%) of 731 patients. Fungal cultures of liver lesions were positive for 34 of 67 patients, most of whom had been culture-positive for the same fungal species (largely Candida) during life. Multivariate analysis revealed that independent predictors of fungal liver infection were deep fungal infection after transplantation (RR, 35), colonization or superficial infection after transplantation (RR, 13), and severe liver dysfunction caused by veno-occlusive disease of the liver and/or graft-versus-host disease (RR, 7). Clinical and laboratory findings during the last month of life revealed no differences between cases and controls. Liver imaging studies performed during the last 15 days of life had a sensitivity of only 18% for detecting fungal liver lesions. |
| Databáze: | OpenAIRE |
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