DNA methylation in epigenetic inheritance of metabolic diseases through the male germ line
| Autor: | Louise Ruby Høj Illum, Sten Lund, Stine Thorhauge Bak, Anders Lade Nielsen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male Inheritance Patterns Biology Germline Epigenesis Genetic 03 medical and health sciences Endocrinology Metabolic Diseases Animals Humans Metabolic Diseases/genetics Epigenetics Molecular Biology Genetics Zygote Base Sequence Spermatozoa/metabolism DNA Methylation Spermatozoa Phenotype Inheritance Patterns/genetics Germ Cells 030104 developmental biology DNA demethylation Histone Germ Cells/metabolism DNA methylation biology.protein Reprogramming DNA Methylation/genetics |
| Zdroj: | Illum, L R, Bak, S T, Lund, S & Nielsen, A L 2018, ' DNA methylation in epigenetic inheritance of metabolic diseases through the male germ line ', Journal of Molecular Endocrinology, vol. 60, no. 2, pp. R39-R56 . https://doi.org/10.1530/JME-17-0189 |
| Popis: | The global rise in metabolic diseases can be attributed to a complex interplay between biology, behavior and environmental factors. This article reviews the current literature concerning DNA methylation-based epigenetic inheritance (intergenerational and transgenerational) of metabolic diseases through the male germ line. Included are a presentation of the basic principles for DNA methylation in developmental programming, and a description of windows of susceptibility for the inheritance of environmentally induced aberrations in DNA methylation and their associated metabolic disease phenotypes. To this end, escapees, genomic regions with the intrinsic potential to transmit acquired paternal epigenetic information across generations by escaping the extensive programmed DNA demethylation that occurs during gametogenesis and in the zygote, are described. The ongoing descriptive and functional examinations of DNA methylation in the relevant biological samples, in conjugation with analyses of non-coding RNA and histone modifications, hold promise for improved delineation of the effect size and mechanistic background for epigenetic inheritance of metabolic diseases. |
| Databáze: | OpenAIRE |
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