Insulin-like growth factor-II is a useful marker to detect hepatocellular carcinoma?
| Autor: | Carmela Morace, Federica Spadaro, Pierluigi Consolo, Carmelo Luigiano, Aldo Spadaro, A. Fortiguerra, R. Bellerone, Stefano Francesco Crinò, Agata Zirilli, G. De Caro, Resta Ml, Angela Alibrandi, M. Cucunato, Oscar Ferraù |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Liver Cirrhosis Male medicine.medical_specialty Cirrhosis Carcinoma Hepatocellular Gastroenterology Sensitivity and Specificity Insulin-Like Growth Factor II Predictive Value of Tests Internal medicine Internal Medicine medicine Carcinoma Biomarkers Tumor Humans Aged Aged 80 and over Receiver operating characteristic business.industry Liver Neoplasms Case-control study Middle Aged medicine.disease Confidence interval Alpha-fetoprotein Diagnosis Hepatocellular carcinoma Insulin-like growth factor-II Liver cirrhosis Endocrinology ROC Curve Hepatocellular carcinoma Predictive value of tests Case-Control Studies Female alpha-Fetoproteins Alpha-fetoprotein business |
| Zdroj: | European journal of internal medicine. 23(6) |
| ISSN: | 1879-0828 |
| Popis: | Background Hepatocellular carcinoma (HCC) is a typical hypervascular tumor. The utility of serum alpha-fetoprotein (α-FP) in its detection is questionable. Over-expression and high circulating levels of insulin-like growth factor-II (IGF-II) were reported in tissue and in serum of patients with HCC. We investigated the diagnostic application of IGF-II in the diagnosis of HCC. Methods Serum IGF-II and α-FP levels were measured in 178 patients (82 with HCC and 96 with liver cirrhosis) and in 30 healthy controls. Spearman test, non parametric combination test and confidence interval analysis were used for statistical evaluation of data. Results The best cut-off values selected by ROC curves were 796 ng/ml for IGF-II and 132 ng/ml for α-FP. IGF-II mean values were higher in patients with HCC than in those with liver cirrhosis (LC) ( p = 0.0001) but lower in LC than in controls ( p = 0.0001). Serum IGF-II levels above cut-off were found in 22% of patients with HCC, in 9.3% of those with cirrhosis and in 20% of controls. α-FP serum levels > 132 ng/ml were observed in 48% of HCC, in 3.1% of LC and in none of control group. By correlation study, serum IGF-II levels were significantly correlated with serum α-FP levels ( r = 0.427, p = 0.0001) and with nodules' diameter ( r = 0.252, p = 0.0130) but not with nodules' number ( p > 0.050). Finally, IGF-II showed lower sensitivity, specificity and predictive values than α-FP. Conclusion Circulating IGF-II is not a useful marker for HCC. Further researches are however needed to evaluate its diagnostic accuracy before and after nutritional adjustment. |
| Databáze: | OpenAIRE |
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