Infection of in vivo differentiated human mast cells with hantaviruses
| Autor: | Detlev H. Krüger, Anika Schielke, Renate Franke, Magda Babina, Andreas Rang, Sven Guhl, Reimar Johne |
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| Rok vydání: | 2010 |
| Předmět: |
Myxovirus Resistance Proteins
Orthohantavirus Cell type viruses Gene Expression Vascular permeability Biology Virus Replication CCL5 Virus GTP-Binding Proteins Interferon Virology Gene expression medicine Humans Mast Cells Chemokine CCL5 Ubiquitins Cells Cultured Reverse Transcriptase Polymerase Chain Reaction virus diseases Interferon-beta ISG15 Viral replication Cytokines RNA Viral medicine.drug |
| Zdroj: | Journal of General Virology. 91:1256-1261 |
| ISSN: | 1465-2099 0022-1317 |
| Popis: | Increased vascular permeability is a key feature of the pathological symptoms caused by hantaviruses. Here, we analysed the interaction between hantaviruses and mast cells, which regulate vascular homeostasis. In highly purified human skin mast cells increasing amounts of Hantaan (HTNV) and, to a lower extent, Prospect Hill (PHV) virions were produced. Replication was confirmed by the production of viral plus-strand RNA as determined by a virus strand-specific RT-PCR. PHV but not HTNV elicited early expression of beta interferon, MxA, ISG15 and CCL5 consistent to studies with other cell types. The data demonstrate that mature mast cells are permissive to infection with hantaviruses. This interaction might contribute to the development of vascular leakage syndrome. |
| Databáze: | OpenAIRE |
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