Local application of tranexamic acid affects tendon healing negatively in the late period
| Autor: | Erdal Uzun, Havva Erdem, Orhan Baş, Soner Çankaya, Alper Çıraklı, Pınar Naile Gürgör |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Administration Topical Cell morphology Achilles Tendon 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Tendon Injuries medicine Animals Orthopedics and Sports Medicine Rats Wistar Tendon healing 030222 orthopedics Wound Healing business.industry Rehabilitation Antifibrinolytic Agents Surgery Tendon Rats Tenocytes medicine.anatomical_structure Late period Tranexamic Acid Hemostasis Orthopedic surgery Achilles tenotomy business Tranexamic acid medicine.drug |
| Zdroj: | Eklem hastaliklari ve cerrahisi = Joint diseasesrelated surgery. 29(1) |
| ISSN: | 1309-0313 |
| Popis: | Objectives This study aims to evaluate the potential adverse effects of tranexamic acid (TA) on tendon healing. Materials and methods Twelve male Wistar-Albino rats (weighing 300 g to 350 g) were used in the study. Rats were divided into two groups. Right legs of the rats were determined as the TA group and left legs as the serum physiologic (SP) group. Bilateral Achilles tenotomy was performed and surgically repaired. For the right side, 1 mL of TA and for the left side, 1 mL of SP were applied. Half of the rats were sacrificed at the third week and the other half at the sixth week and tendon samples were collected from the extremities. Histological analyses were performed according to the tendon scoring system (Bonar classification). Results Tenocyte cell morphology was better in the third week in TA group than in SP group. In terms of colloidal organization, SP groups gave superior results in all weeks. An analysis of total tendon healing scores revealed that the results of the third week TA groups were superior to the results of the sixth week TA groups. Tenocyte morphology and total tendon healing scores of rats in the sixth week TA group were statistically significantly lower compared to the third week TA group (tenocyte morphology p=0.009, total score p=0.041). Conclusion In this study, we detected that locally administered TA has an adverse effect on tendon healing in late period. However, further immunohistochemical and biomechanical studies are needed to support these results. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|