Retropharyngeal Lymph Node Metastasis in Nasopharyngeal Carcinoma: Prognostic Value and Staging Categories
| Autor: | Nian-Ji Cui, Jing Feng Zong, Lizhi Liu, Chunyan Cui, Ai-Hua Lin, Ling-Long Tang, Tai-Xiang Lu, Jun Ma, Li Li |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Oncology Cancer Research medicine.medical_specialty Adolescent medicine.medical_treatment Disease-Free Survival Metastasis Retropharyngeal lymph nodes Internal medicine medicine Humans Survival analysis Aged Neoplasm Staging Retrospective Studies business.industry Incidence (epidemiology) Hazard ratio Nasopharyngeal Neoplasms Retrospective cohort study Middle Aged Prognosis medicine.disease Survival Analysis Radiation therapy Nasopharyngeal carcinoma Lymphatic Metastasis Female Tomography X-Ray Computed business |
| Zdroj: | Clinical Cancer Research. 13:1445-1452 |
| ISSN: | 1557-3265 1078-0432 |
| Popis: | Purpose: To investigate the incidence, prognostic value, and staging categories of retropharyngeal lymph node (RLN) metastasis in nasopharyngeal carcinoma (NPC). Experimental Design: We did a retrospective review of the data from 749 biopsy-proved nonmetastatic NPC patients. All patients had undergone contrast-enhanced computed tomography and had radiotherapy as their primary treatment. Results: The incidence of RLN metastasis was 51.5%. After adjusting for tumor (T) and node (N) classifications, a borderline significant difference of distant metastasis-free survival (DMFS) rates was observed between patients with or without RLN metastasis. In N0 disease, the presence of RLN metastasis was a significant independent predictor for overall survival (OS), loco-regional relapse-free survival, and DMFS in multivariate Cox modeling analysis. No significant difference was observed in all end points between patients with unilateral and bilateral RLN metastasis. The hazard ratios of death and distant failure for N0 with RLN metastasis were similar to N1. The survival curve of OS and DMFS for N0 disease with RLN metastasis had approximated that of N1 disease. The survival curve of OS for T1 disease with RLN metastasis was approximately the same as T2 disease. However, the survival curve of DMFS for T1 disease with RLN metastasis was approximately the same as in T3 disease. Conclusions: RLN metastasis has a tendency to affect the DMFS rates of patients with NPC. Retropharyngeal node involvement has a negative effect on the prognosis of N0 disease. RLN metastasis should be classified as N1. |
| Databáze: | OpenAIRE |
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