Functional role of the ER stress transducer IRE1α in CF airway epithelial inflammation

Autor:	Carla M.P. Ribeiro, Emily A. Hull-Ryde
Rok vydání:	2022
Předmět:	Inflammation Pharmacology Ribonucleases Cystic Fibrosis Endoribonucleases Drug Discovery Humans Protein Serine-Threonine Kinases Endoplasmic Reticulum Stress Inositol
Zdroj:	Current Opinion in Pharmacology. 65:102258
ISSN:	1471-4892
Popis:	Excessive and chronic airway inflammation associated with increased morbidity and mortality is a hallmark of cystic fibrosis (CF) airway disease. Previous studies underscored the role of endoplasmic reticulum (ER) signaling in CF airway inflammatory responses. In this review we discuss 1) how airway inflammation induces ER stress-triggered activation of the unfolded protein response and 2) the functional importance of the ER stress transducer inositol requiring enzyme 1α (IRE1α) in CF airway epithelial inflammatory responses. We also briefly review the current understanding of IRE1α activation and the development of small molecules aimed at modulating IRE1α kinase and RNase activities. Inhibition of IRE1α kinase and RNase may be considered as a novel therapeutic strategy to ameliorate the robust inflammatory status of CF airways.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57635f1e75592ed37ef34ed3cf062b6f https://doi.org/10.1016/j.coph.2022.102258 Zobrazit plný text záznamu Full Text from ScienceDirect