Effect of exercise on redistribution and clearance of inhaled particles from hamster lungs
| Autor: | Joseph D. Brain, T. D. Sweeney, A. F. Tryka |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Male
Pathology medicine.medical_specialty Physiology Metabolic Clearance Rate Hamster Physical exercise Motor Activity Excretion Physiology (medical) Cricetinae Respiration medicine Animals Lung volumes Tissue Distribution Respiratory system Lung Aerosols Inhalation Gold Radioisotopes Mesocricetus Chemistry respiratory system medicine.anatomical_structure |
| Zdroj: | Journal of applied physiology (Bethesda, Md. : 1985). 68(3) |
| ISSN: | 8750-7587 |
| Popis: | Does exercise alter the redistribution and clearance of particles from the lungs? Sedentary hamsters and hamsters that were exercise trained by voluntary wheel running for the previous 5 wk were exposed to a 198Au-labeled aerosol for 25 min. Six trained and 6 sedentary animals were killed within 5 min after the exposure (day 0); the same number were killed 5 days later. The trained hamsters ran ad libitum during those 5 days. The lungs of all animals were excised, dried at total lung capacity, sliced into 1-mm-thick sections, and dissected into pieces that were counted for radioactivity and weighed. On day 0, trained hamsters had 80% more particles per milligram of lung than sedentary hamsters, although both were exposed under identical conditions of restraint. After five days, exercising hamsters cleared 38% of the particles present at day 0, whereas sedentary animals removed only 15%. Significant clearance was observed from the middle lung regions of sedentary hamsters and from all lung regions in exercising hamsters. We conclude that exercise can enhance the redistribution and clearance of particles from the lungs; the mechanisms responsible are as yet unclear. |
| Databáze: | OpenAIRE |
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