Association betweenIL17A/IL17RAGene Polymorphisms and Susceptibility to Alopecia Areata in the Korean Population
| Autor: | Hwi Jun Kim, Bark-Lynn Lew, Woo-Young Sim, Hee-Ryung Cho, Sik Haw, Joo-Ho Chung |
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| Rok vydání: | 2012 |
| Předmět: |
Autoimmune disease
integumentary system business.industry Alopecia areata Single-nucleotide polymorphism Dermatology medicine.disease Hair follicle Single nucleotide polymorphism Hair loss medicine.anatomical_structure Immunology medicine Original Article Gene polymorphism IL17A Interleukin-17 receptors A skin and connective tissue diseases business Allele frequency Interleukin-17A |
| Zdroj: | Annals of Dermatology |
| ISSN: | 2005-3894 1013-9087 |
| DOI: | 10.5021/ad.2012.24.1.61 |
| Popis: | Background Alopecia areata is marked by autoimmune assault on the hair follicle resulting in hair loss. T helper 17 cell subset has important roles in protecting the host against extracellular pathogens, however, also promotes inflammatory pathology in autoimmune disease, and it expresses both interleukin (IL)-17A and IL-17F, which can signal via the IL-17 receptor A. Objective To investigate the significance of IL17A and IL17RA gene polymorphisms in the susceptibility to alopecia areata. Methods We conducted case-control association study of 238 alopecia areata patients and 270 matched healthy controls. Allele frequency of total 2 single nucleotide polymorphims in the IL17A gene and 4 single nucleotide polymorphims in the IL17RA gene were studied. The statistical analyses were performed according to onset age, the presence of familyhistory, clinical subtypes, and presence of nail involvement or body hair involvement. Results One single nucleotide polymorphim (rs879577) of IL17RA gene showed significant difference between alopecia areata patients group and controls group (p= 0.0288). One single nucleotide polymorphim (rs4819554) of IL17RA gene showed significant difference between the early onset and late onset alopecia areata (p=0.0421). Conclusion IL17RA gene polymorphism might contribute to the increased susceptibility to alopecia areata in Korean population, and IL17RA gene polymorphism may be associated with onset age. |
| Databáze: | OpenAIRE |
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