Transcriptomic features of primary prostate cancer and their prognostic relevance to castration-resistant prostate cancer
Autor: | Seon-Young Kim, Wun-Jae Kim, Seok Joong Yun, Ho Won Kang, Yun-Sok Ha, Young-Ki Choi, Jang-Seong Kim, Jayoung Kim, Yung Hyun Choi, Eun-Jong Cha, Ye-Hwan Kim, Sung-Kwon Moon, Pildu Jeong, Sun Jin Kim, Seon-Kyu Kim, Jong-Lyul Park, Jeong-Hwan Kim |
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Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty markers urologic and male genital diseases medicine.disease_cause Transcriptome 03 medical and health sciences Prostate cancer disease progression 0302 clinical medicine Internal medicine Gene expression Medicine CRPC business.industry Microarray analysis techniques Hazard ratio medicine.disease HNF1A Androgen receptor 030104 developmental biology 030220 oncology & carcinogenesis gene expression prognosis business Carcinogenesis Research Paper |
Zdroj: | Oncotarget |
ISSN: | 1949-2553 |
Popis: | Although various mechanisms of castration-resistant prostate cancer (CRPC) have been discovered, reliable biomarkers for monitoring CRPC progression are lacking. We sought to identify molecules that predict the progression of advanced prostate cancer (AdvPC) into CRPC. The study used primary-site samples (N=45 for next-generation sequencing (NGS); N=243 for real-time polymerase chain reaction) from patients with prostate cancer (PC). Five public databases containing microarray data of AdvPC and CRPC samples were analyzed. The NGS data showed that each progression step in PC associated with distinct gene expression profiles. Androgen receptor (AR) associated with tumorigenesis, advanced progression, and progression into CRPC. Analysis of the paired and unpaired AdvPC and CRPC samples in the NGS cohort showed that 15 genes associated with progression into CRPC. This was validated by cohort-1 and public database analyses. Analysis of the third cohort with AdvPC showed that higher serine peptidase inhibitor, Kazal type 1 (SPINK1) and lower Sp8 transcription factor (SP8) expression associated with progression into CRPC (log-rank test, both P |
Databáze: | OpenAIRE |
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