Effects of β-hydroxybutyrate on cognition in patients with type 2 diabetes
| Autor: | Jonas Schultz Ingerslev, Mogens Fenger, Dorte Aalund Olsen, Malin Nilsson, Jørgen Rungby, Nicole Jacqueline Jensen, Kamilla W. Miskowiak, Mette Zander, Mads Svart, Niels Møller |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Type 2 diabetes 03 medical and health sciences Cognition 0302 clinical medicine Endocrinology Insulin resistance Double-Blind Method Memory Diabetes mellitus Internal medicine medicine Humans Effects of sleep deprivation on cognitive performance Aged Cross-Over Studies 3-Hydroxybutyric Acid medicine.diagnostic_test business.industry Wechsler Adult Intelligence Scale General Medicine Neuropsychological test Middle Aged Mental Status and Dementia Tests medicine.disease Memory Short-Term Diabetes Mellitus Type 2 030220 oncology & carcinogenesis Anesthesia Ketone bodies Female Verbal memory business |
| Zdroj: | Jensen, N J, Nilsson, M, Ingerslev, J S, Olsen, D A, Fenger, M, Svart, M, Møller, N, Zander, M, Miskowiak, K W & Rungby, J 2020, ' Effects of β-hydroxybutyrate on cognition in patients with type 2 diabetes ', European Journal of Endocrinology, vol. 182, no. 2, pp. 233-242 . https://doi.org/10.1530/EJE-19-0710 |
| DOI: | 10.1530/EJE-19-0710 |
| Popis: | Objective Cognitive impairment in type 2 diabetes is associated with cerebral glucose hypometabolism. Providing a glucose substitute such as ketone bodies might restore metabolic balance in glucose-compromised neurones and improve cognitive performance. We aimed to investigate if β-hydroxybutyrate (ketone body) infusion acutely affects cognitive performance, measured by a neuropsychological test battery, in patients with type 2 diabetes. Design Randomised, placebo-controlled, double-blind cross-over trial. Methods Eighteen patients with type 2 diabetes received i.v. ketone body (β-hydroxybutyrate) and placebo (saline) infusion in a randomised order on two separate occasions. On both days of examination, blood glucose was clamped at 7.5 mmol/L and a neuropsychological test battery was used to assess global cognitive performance (primary outcome) and specialized cognitive measures of verbal memory, working memory, executive function, psychomotor speed, and sustained attention. Results During neurocognitive testing, β-hydroxybutyrate concentrations were 2.4 vs 0.1 mmol/L. Working memory assessed by Wechsler Adult Intelligence Scale letter-number-sequencing significantly improved by 1.6 points (95% CI: 0.7, 2.4; non-adjusted P P = 0.012). Conclusions Ketone infusion specifically improved working memory performance in patients with type 2 diabetes in the absence of changes in global cognition. |
| Databáze: | OpenAIRE |
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