Pistacia weinmannifolia ameliorates cigarette smoke and lipopolysaccharide-induced pulmonary inflammation by inhibiting interleukin-8 production and NF-κB activation
| Autor: | Min-Gu Kim, Sangho Choi, Sang Woo Lee, Kyung-Seop Ahn, Tae Young Kim, Hyung Won Ryu, Sei-Ryang Oh, Ok Kyoung Kwon, Wan Yi Li, Jae-Won Lee, Su Ui Lee, Mun Ok Kim, Jae Kyoung Lee, Tae Kyu Oh |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Lipopolysaccharides Lipopolysaccharide Neutrophils Pharmacology airway inflammation NF-κB chronic obstructive pulmonary disease Cell Line 03 medical and health sciences chemistry.chemical_compound Mice 0302 clinical medicine Smoke Genetics Pneumonia Bacterial Medicine Animals Interleukin 8 COPD Lung biology medicine.diagnostic_test business.industry Plant Extracts Tumor Necrosis Factor-alpha Monocyte Interleukin-8 NF-kappa B Interleukin General Medicine Articles medicine.disease Disease Models Animal 030104 developmental biology medicine.anatomical_structure Bronchoalveolar lavage Pistacia weinmannifolia chemistry 030220 oncology & carcinogenesis Neutrophil elastase Pistacia biology.protein Cytokines Inflammation Mediators business |
| Zdroj: | International Journal of Molecular Medicine |
| ISSN: | 1791-244X 1107-3756 |
| Popis: | Pistacia weinmannifolia (PW) has been used in traditional Chinese medicine to treat headaches, dysentery, enteritis and influenza. However, PW has not been known for treating respiratory inflammatory diseases, including chronic obstructive pulmonary disease (COPD). The present in vitro analysis confirmed that PW root extract (PWRE) exerts anti-inflammatory effects in phorbol myristate acetate- or tumor necrosis factor α (TNF-α)-stimulated human lung epithelial NCI-H292 cells by attenuating the expression of interleukin (IL)-8, IL-6 and Mucin A5 (MUC5AC), which are closely associated with the pulmonary inflammatory response in the pathogenesis of COPD. Thus, the aim of the present study was to evaluate the protective effect of PWRE on pulmonary inflammation induced by cigarette smoke (CS) and lipopoly-saccharide (LPS). Treatment with PWRE significantly reduced the quantity of neutrophils and the levels of inflammatory molecules and toxic molecules, including tumor TNF-α, IL-6, IL-8, monocyte chemoattractant protein-1, neutrophil elastase and reactive oxygen species, in the bronchoalveolar lavage fluid of mice with CS- and LPS-induced pulmonary inflammation. PWRE also attenuated the influx of inflammatory cells in the lung tissues. Furthermore, PWRE downregulated the activation of nuclear factor-κB and the expression of phosphodiesterase 4 in the lung tissues. Therefore, these findings suggest that PWRE may be a valuable adjuvant treatment for COPD. |
| Databáze: | OpenAIRE |
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