Cytogenetic consequences after occupational exposure to antineoplastic drugs
| Autor: | Aleksandra Fučić, Anamarija Jazbec, Đurđica Šešo-Šimić, August Mijić, Rudolf Tomek |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Drug
Adult medicine.medical_specialty DNA damage Health Toxicology and Mutagenesis media_common.quotation_subject Mitosis Nurses Sister chromatid exchange Antineoplastic Agents Biology Pharmacology Chromosome aberration Clastogen Cytogenetics Occupational Exposure antineoplastic drug biomonitoring chromosome aberration SCE micronucleus assay mitotic activity smoking occupational exposure Genetics medicine Humans Lymphocytes media_common Chromosome Aberrations Micronucleus Tests Case-Control Studies Micronucleus test Female Safety Micronucleus Sister Chromatid Exchange DNA Damage Environmental Monitoring Mutagens |
| Zdroj: | Mutation research. 416(1-2) |
| ISSN: | 0027-5107 |
| Popis: | Cytogenetic monitoring was carried out on a group of 38 nurses who reconstitute antineoplastic drugs in order to determine the extent of chromosomal damage. Genotoxic activities of antineoplastic drugs are studied by chromosome aberration assay, micronucleus assay, sister chromatid exchange (SCE) frequency high frequency cells (HFC) analysis, and mitotic activity of peripheral lymphocytes. Results confirmed that occupational exposure to a mixture of antineoplastic drugs may cause genome damages. The results of this study show that biomonitoring after exposure to a mixture of antineoplastic drugs which express clastogenic and aneugenic activity should involve a battery of cytogenetic methods. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect