Interleaved Carbon Minibeams: An Experimental Radiosurgery Method With Clinical Potential
| Autor: | Giovanna R. Fois, Nicolle R. Desnoyers, John A. Olschowka, Ruiliang Wang, Allen G. Meek, Adam Rusek, Dardo Tomasi, I. Dioszegi, Hedok Lee, F. Avraham Dilmanian, Bari Dane, Jane Y. Park, Patricia K. Coyle, Sean D. Hurley, M. Kerry O'Banion |
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| Rok vydání: | 2012 |
| Předmět: |
Organs at Risk
Cancer Research medicine.medical_treatment Bragg peak Radiation Radiosurgery Patient Positioning medicine Relative biological effectiveness Animals Radiology Nuclear Medicine and imaging Behavior Animal medicine.diagnostic_test Brain Neoplasms business.industry Brain Radiotherapy Dosage Magnetic resonance imaging Magnetic Resonance Imaging Carbon Radiation therapy Radiation Injuries Experimental Oncology Absorbed dose Rabbits business Nuclear medicine Monte Carlo Method Relative Biological Effectiveness Beam (structure) Biomedical engineering |
| Zdroj: | International Journal of Radiation Oncology*Biology*Physics. 84:514-519 |
| ISSN: | 0360-3016 |
| Popis: | Purpose To evaluate the efficacy of "interleaved carbon minibeams" for ablating a 6.5-mm target in a rabbit brain with little damage to the surrounding brain. The method is based on the well-established tissue-sparing effect of arrays of thin planes of radiation. Methods and Materials Broad carbon beams from the National Aeronautics and Space Agency Space Radiation Facility at Brookhaven National Laboratory were segmented into arrays of parallel, horizontal, 0.3-mm-thick planar beams (minibeams). The minibeams' gradual broadening in tissues resulted in 0.525-mm beam thickness at the target's proximal side in the spread-out Bragg peak. Interleaving was therefore implemented by choosing a 1.05 mm beam spacing on-center. The anesthetized rabbit, positioned vertically on a stage capable of rotating about a vertical axis, was exposed to arrays from four 90° angles, with the stage moving up by 0.525 mm in between. This produced a solid radiation field at the target while exposing the nontargeted tissues to single minibeam arrays. The target "physical" absorbed dose was 40.2 Gy. Results The rabbit behaved normally during the 6-month observation period. Contrast magnetic resonance imaging and hematoxylin and eosin histology at 6 months showed substantial focal target damage with little damage to the surrounding brain. Conclusion We plan to evaluate the method's therapeutic efficacy by comparing it with broad-beam carbon therapy in animal models. The method's merits would combine those of carbon therapy ( i.e. , tight target dose because of the carbon's Bragg-peak, sharp dose falloff, and high relative biological effectiveness at the target), together with the method's low impact on the nontargeted tissues. The method's smaller impact on the nontargeted brain might allow carbon therapy at higher target doses and/or lower normal tissue impact, thus leading to a more effective treatment of radioresistant tumors. It should also make the method more amenable to administration in either a single dose fraction or in a small number of fractions. |
| Databáze: | OpenAIRE |
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