Clinical and Biological Characterization of Skin Pigmentation Diversity and Its Consequences on UV Impact

Autor: Sandra Del Bino, Christine Duval, Françoise Bernerd
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
Acute effects
constitutive skin pigmentation
Skin Neoplasms
melanocyte
Erythema
Sunburn
Skin Pigmentation
Review
lcsh:Chemistry
030207 dermatology & venereal diseases
0302 clinical medicine
lcsh:QH301-705.5
Spectroscopy
integumentary system
General Medicine
Computer Science Applications
Phenotype
medicine.anatomical_structure
Sun exposure
medicine.symptom
UV sensitivity
medicine.medical_specialty
Ultraviolet Rays
Melanocyte
Biology
Polymorphism
Single Nucleotide
Skin Diseases
Catalysis
Inorganic Chemistry
03 medical and health sciences
medicine
pigmentary disorders
Animals
Humans
Genetic Predisposition to Disease
Physical and Theoretical Chemistry
Molecular Biology
Melanins
Skin response
Organic Chemistry
Phenotypic trait
medicine.disease
Dermatology
030104 developmental biology
lcsh:Biology (General)
lcsh:QD1-999
Skin color
phototype
sense organs
Pigmentation Disorders
Zdroj: International Journal of Molecular Sciences, Vol 19, Iss 9, p 2668 (2018)
International Journal of Molecular Sciences
ISSN: 1422-0067
Popis: Skin color diversity is the most variable and noticeable phenotypic trait in humans resulting from constitutive pigmentation variability. This paper will review the characterization of skin pigmentation diversity with a focus on the most recent data on the genetic basis of skin pigmentation, and the various methodologies for skin color assessment. Then, melanocyte activity and amount, type and distribution of melanins, which are the main drivers for skin pigmentation, are described. Paracrine regulators of melanocyte microenvironment are also discussed. Skin response to sun exposure is also highly dependent on color diversity. Thus, sensitivity to solar wavelengths is examined in terms of acute effects such as sunburn/erythema or induced-pigmentation but also long-term consequences such as skin cancers, photoageing and pigmentary disorders. More pronounced sun-sensitivity in lighter or darker skin types depending on the detrimental effects and involved wavelengths is reviewed.
Databáze: OpenAIRE
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