Synthesis of cyclooxygenase metabolites of 8,9-epoxyeicosatrienoic acid (EET): 11- and 15-hydroxy 8,9-EETs

Autor:	Bruce D. Hammock, Bogdan Barnych, Tomas Cajka, Amy A. Rand, Kin Sing Stephen Lee
Rok vydání:	2017
Předmět:	0301 basic medicine 14-Eicosatrienoic Acid Stereochemistry Epoxyeicosatrienoic acid 01 natural sciences Biochemistry Article Synthetic materials Medicinal and Biomolecular Chemistry 03 medical and health sciences chemistry.chemical_compound 8 11 14-Eicosatrienoic Acid Physical and Theoretical Chemistry Molecular Structure biology 010405 organic chemistry Organic Chemistry Stereoisomerism Lipid signaling 0104 chemical sciences 030104 developmental biology chemistry Cyclooxygenase 2 cardiovascular system biology.protein lipids (amino acids peptides and proteins) Cyclooxygenase
Zdroj:	Organic & biomolecular chemistry, vol 15, iss 20
ISSN:	1477-0539 1477-0520
Popis:	COX metabolites of 8,9-EET, previously observed as potent mitogenic lipid mediators, were synthesized for the first time by using two synthetic approaches. These synthetic materials allow for structural confirmation of COX metabolites of 8,9-EET and further study of their biological roles.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::575630d48769869543dfc59e93d23b3d https://doi.org/10.1039/c7ob00789b Zobrazit plný text záznamu