Fresh versus frozen embryo transfer after gonadotropin-releasing hormone agonist trigger in gonadotropin-releasing hormone antagonist cycles among high responder women: A randomized, multi-center study
| Autor: | Nasim Tabibnejad, Homa Oskouian, Maryam Farid Mojtahedi, Mehrdad Soleimani, Mohammaad Ali Khalili, Behrouz Aflatoonian, Mahnaz Mansoori-Torshizi, Peter Humaidan, Nastaran Aflatoonian, Mohammad Hossein Amir-Arjmand, Abbas Aflatoonian |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
lcsh:QH471-489 medicine.drug_class medicine.medical_treatment Reproductive Outcome Ovarian hyperstimulation syndrome GnRHa trigger lcsh:Gynecology and obstetrics Gonadotropin-releasing hormone antagonist Human chorionic gonadotropin Andrology 03 medical and health sciences 0302 clinical medicine Embryo cryopreservation Gonadotropin-releasing hormone agonist Frozen-thawed embryo transfer GnRH antagonist lcsh:Reproduction Fresh Medicine lcsh:RG1-991 Pregnancy 030219 obstetrics & reproductive medicine In vitro fertilisation business.industry Fresh embryo transfer Obstetrics and Gynecology medicine.disease Embryo transfer 030104 developmental biology Reproductive Medicine OHSS Original Article business |
| Zdroj: | International Journal of Reproductive Biomedicine International Journal of Reproductive BioMedicine, Vol 16, Iss 1, Pp 9-18 (2018) Aflatoonian, A, Mansoori-Torshizi, M, Farid Mojtahedi, M, Aflatoonian, B, Khalili, M A, Amir-Arjmand, M H, Soleimani, M, Aflatoonian, N, Oskouian, H, Tabibnejad, N & Humaidan, P 2018, ' Fresh versus frozen embryo transfer after gonadotropin-releasing hormone agonist trigger in gonadotropin-releasing hormone antagonist cycles among high responder women : A randomized, multi-center study ', International journal of reproductive biomedicine (Yazd, Iran), vol. 16, no. 1, pp. 9-18 . |
| ISSN: | 2476-3772 2476-4108 |
| DOI: | 10.29252/ijrm.16.1.9 |
| Popis: | Background: The use of embryo cryopreservation excludes the possible detrimental effects of ovarian stimulation on the endometrium, and higher reproductive outcomes following this policy have been reported. Moreover, gonadotropin-releasing hormone agonist trigger in gonadotropin-releasing hormone (GnRH) antagonist cycles as a substitute for standard human chorionic gonadotropin trigger, minimizes the risk of ovarian hyperstimulation syndrome (OHSS) in fresh as well as frozen embryo transfer cycles (FET).Objective: To compare the reproductive outcomes and risk of OHSS in fresh vs frozen embryo transfer in high responder patients, undergoing in vitro fertilization triggered with a bolus of GnRH agonist.Materials and Methods: In this randomized, multi-centre study, 121 women undergoing FET and 119 women undergoing fresh ET were investigated as regards clinical pregnancy as the primary outcome and the chemical pregnancy, live birth, OHSS development, and perinatal data as secondary outcomes.Results: There were no significant differences between FET and fresh groups regarding chemical (46.4% vs. 40.2%, p=0.352), clinical (35.8% vs. 38.3%, p=0.699), and ongoing (30.3% vs. 32.7%, p=0.700) pregnancy rates, also live birth (30.3% vs. 29.9%, p=0.953), perinatal outcomes, and OHSS development (35.6% vs. 42.9%, p=0.337). No woman developed severe OHSS and no one required admission to hospital.Conclusion: Our findings suggest that GnRHa trigger followed by fresh transfer with modified luteal phase support in terms of a small human chorionic gonadotropin bolus is a good strategy to secure good live birth rates and a low risk of clinically relevant OHSS development in in vitro fertilization patients at risk of OHSS. |
| Databáze: | OpenAIRE |
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