Blood fatty acid analysis reveals similar n-3 fatty acid composition in non-pregnant and pregnant women and their neonates in an Israeli pilot study
| Autor: | Yehuda Kamari, Dror Harats, Matan Anteby, Alicia Leikin-Frenkel, Aviv Shaish, Hofit Cohen, Michal Kandel-Kfir, Aya Mohr Sasson, Ayelet Harari, Israel Hendler, Roni Rahav |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Docosahexaenoic Acids Normal diet Offspring Clinical Biochemistry Physiology Pilot Projects chemistry.chemical_compound Pregnancy Fatty Acids Omega-6 Fatty Acids Omega-3 Humans Medicine Israel gamma-Linolenic Acid Carbon-Oxygen Ligases Maternal-Fetal Exchange Triglycerides reproductive and urinary physiology chemistry.chemical_classification Fetus Fatty Acids Essential Fatty acid metabolism Arabidopsis Proteins business.industry Infant Newborn alpha-Linolenic Acid Fatty acid Maternal Nutritional Physiological Phenomena Cell Biology medicine.disease chemistry Docosahexaenoic acid Case-Control Studies Fatty Acids Unsaturated Female business Polyunsaturated fatty acid |
| Zdroj: | Prostaglandins, Leukotrienes and Essential Fatty Acids. 173:102339 |
| ISSN: | 0952-3278 |
| Popis: | Maternal docosahexaenoic acid (DHA) is required during pregnancy to supply for normal fetal growth and development. This pilot study aimed to assess the unknown fatty acid (FA) composition in a cohort of non-pregnant and pregnant Israeli women at term and their offspring on a normal diet without n-3 FA supplementation. The fatty acid profile, analyzed using gas chromatography, showed significantly higher plasma monounsaturated (MUFA) and lower n-6 FA percent distribution with similar n-3 index, in pregnant compared to non-pregnant women. RBC exhibited significantly higher MUFA with similar n-3 index, in pregnant compared to non-pregnant women. N-3 FA significantly correlated between neonates’ plasma, with higher n-3 index, and pregnant women's DHA. Conclusion: DHA levels in non-pregnant and pregnant Israeli women at term were comparable and the DHA in pregnant women's plasma positively correlated with their neonate's level, suggesting an efficient mother-fetus FA transfer and/or fetal fatty acid metabolism to longer FA products. |
| Databáze: | OpenAIRE |
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