Increased α2- and β1-adrenoceptor densities in postmortem brain of subjects with depression: Differential effect of antidepressant treatment
| Autor: | Guadalupe Rivero, Luis F. Callado, Romano La Harpe, Ane M. Gabilondo, Jesús A. García-Sevilla, J. Javier Meana |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Prefrontal Cortex Context (language use) Selective antagonist Rats Sprague-Dawley Receptors Adrenergic alpha-2 Reference Values Internal medicine medicine Animals Humans Prefrontal cortex Depression (differential diagnoses) Depressive Disorder Major Postmortem brain Depression business.industry Middle Aged medicine.disease Antidepressive Agents Rats Psychiatry and Mental health Clinical Psychology β1 adrenoceptor Endocrinology Anesthesia Major depressive disorder Antidepressant Female Receptors Adrenergic beta-1 business Signal Transduction |
| Zdroj: | Journal of Affective Disorders. 167:343-350 |
| ISSN: | 0165-0327 |
| DOI: | 10.1016/j.jad.2014.06.016 |
| Popis: | Background Brain α2- and β-adrenoceptor alterations have been suggested in suicide and major depressive disorder. Methods The densities of α2-, β1- and β2-adrenoceptors in postmortem prefrontal cortex of 26 subjects with depression were compared with those of age-, gender- and postmortem delay-matched controls. The effect of antidepressant treatment on α2- and β-adrenoceptor densities was also evaluated. α2- and β-adrenoceptor densities were measured by saturation experiments with respective radioligands [3H]UK14304 and [3H]CGP12177. β1- and β2-adrenoceptor subtype densities were dissected by means of β1-adrenoceptor selective antagonist CGP20712A. Results Both, α2- and β1-adrenoceptors densities were higher in antidepressant-free depressed subjects (n=14) than those in matched controls (Δ~24%, p=0.013 and Δ~20%, p=0.044, respectively). In antidepressant-treated subjects (n=12), α2-adrenoceptor density remained increased over that in controls (Δ~20%), suggesting a resistance of α2-adrenoceptors to the down-regulatory effect of antidepressants. By contrast, β1-adrenoceptor density in antidepressant-treated depressed subjects was not different from controls, suggesting a possible down-regulation by antidepressants. The down-regulation of β1-adrenoceptor density in antidepressant-treated depressed subjects differs from the unaltered β1-adrenoceptor density observed in citalopram-treated rats and in a group of non-depressed subjects also treated with antidepressants (n=6). β2-adrenoceptor density was not altered in depressed subjects independently of treatment. Limitations Antidepressant-treated subjects had been treated with a heterogeneous variety of antidepressant drugs. The results should be understood in the context of suicide victims with depression. Conclusions These results show the up-regulation of brain α2- and β1-adrenoceptors in depression and suggest that the regulation induced by chronic antidepressant treatment would be altered in these subjects. |
| Databáze: | OpenAIRE |
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